selected Publications

Schafer, S.T., Mansour, A.A., Schlachetzki, J.C.M., Pena, M., Ghassemzadeh, S., Mitchell, L., Mar, A., Quang, D., Stumpf, S., Ortiz, I.S., Lana, A.J., Baek, C., Zaghal, R., Glass, C.K., Nimmerjahn, A., Gage, F.H. An in vivo neuroimmune organoid model to study human microglia phenotypes. (2023) Cell. 186(10):2111-2126.e20. DOI: 10.1016/j.cell.2023.04.022

Herdy, J.R., Traxler, L., Agarwal, R.K., Karbacher, L., Schlachetzki, J.C.M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C.K., Mertens, J., Gage, F.H. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease. (2022) Cell Stem Cell. 29(12):1637-1652.e6. DOI: 10.1016/j.stem.2022.11.010

Gage, F.H. Adult neurogenesis in mammals. (2019) Science. 364(6443):827-828. DOI: 10.1126/science.aav6885

Marchetto, M.C., Hrvoj-Mihic, B., Kerman, B.E., Yu, D.X., Vadodaria, K.C., Linker, S.B., Narvaiza, I., Santos, R., Denli, A.M., Mendes, A.P., Oefner, R., Cook, J., McHenry, L., Grasmick, J.M., Heard, K., Fredlender, C., Randolph-Moore, L., Kshirsagar, R., Xenitopoulos, R., Chou, G., Hah, N., Muotri, A.R., Padmanabhan, K., Semendeferi, K., Gage, F.H. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. (2019) Elife. 8. DOI: 10.7554/eLife.37527

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

all Publications

Fernandes, S., Revanna, J., Pratt, J., Hayes, N., Marchetto, M.C., Gage, F.H. Modeling Alzheimer’s disease using human cell derived brain organoids and 3D models. (2024) Frontiers in Neuroscience. 18:1434945. DOI: 10.3389/fnins.2024.1434945

Minhas, P.S., Jones, J.R., Latif-Hernandez, A., Sugiura, Y., Durairaj, A.S., Wang, Q., Mhatre, S.D., Uenaka, T., Crapser, J., Conley, T., Ennerfelt, H., Jung, Y.J., Liu, L., Prasad, P., Jenkins, B.C., Ay, Y.A., Matrongolo, M., Goodman, R., Newmeyer, T., Heard, K., Kang, A., Wilson, E.N., Yang, T., Ullian, E.M., Serrano, G.E., Beach, T.G., Wernig, M., Rabinowitz, J.D., Suematsu, M., Longo, F.M., McReynolds, M.R., Gage, F.H., Andreasson, K.I. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies. (2024) Science. 385(6711):eabm6131. DOI: 10.1126/science.abm6131

Schmidt, T.T., Tyer, C., Rughani, P., Haggblom, C., Jones, J.R., Dai, X., Frazer, K.A., Gage, F.H., Juul, S., Hickey, S., Karlseder, J. High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer. (2024) Nature Communications. 15(1):5149. DOI: 10.1038/s41467-024-48917-7

Phang, H.J., Heimler, S.R., Scandalis, L.M., Wing, D., Moran, R., Nichols, J.F., Moreno, D., Shadel, G.S., Gage, F.H., Molina, A.J.A. Protocol for the San Diego Nathan Shock Center Clinical Cohort: a new resource for studies of human aging. (2024) BMJ Open. 14(6):e082659. DOI: 10.1136/bmjopen-2023-082659

Herdy, J.R., Mertens, J., Gage, F.H. Neuronal senescence may drive brain aging. LINK TO FREE FULL-TEXT https://www.science.org/stoken/author-tokens/ST-1962/full (2024) Science. 384(6703):1404-1406. DOI: 10.1126/science.adi3450

Minhas, P.S., Jones, J.R., Latif-Hernandez, A., Sugiura, Y., Durairaj, A.S., Uenaka, T., Wang, Q., Mhatre, S.D., Liu, L., Conley, T., Ennerfelt, H., Jung, Y.J., Prasad, P., Jenkins, B.C., Goodman, R., Newmeyer, T., Heard, K., Kang, A., Wilson, E.N., Ullian, E.M., Serrano, G.E., Beach, T.G., Rabinowitz, J.D., Wernig, M., Suematsu, M., Longo, F.M., McReynolds, M.R., Gage, F.H., Andreasson, K.I. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies. (2024) bioRxiv. DOI: 10.1101/2024.06.23.598940

Stern, S., Zhang, L., Wang, M., Wright, R., Rosh, I., Hussein, Y., Stern, T., Choudhary, A., Tripathi, U., Reed, P., Sadis, H., Nayak, R., Shemen, A., Agarwal, K., Cordeiro, D., Peles, D., Hang, Y., Mendes, A.P.D., Baul, T.D., Roth, J.G., Coorapati, S., Boks, M.P., McCombie, W.R., Hulshoff Pol, H., Brennand, K.J., Réthelyi, J.M., Kahn, R.S., Marchetto, M.C., Gage, F.H. Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission. (2024) Molecular Psychiatry. DOI: 10.1038/s41380-024-02561-1

Tripathi, U., Rosh, I., Ben Ezer, R., Nayak, R., Hussein, Y., Choudhary, A., Djamus, J., Manole, A., Houlden, H., Gage, F.H., Stern, S. Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations. (2024) NPJ Parkinsons Dis. 10(1):103. DOI: 10.1038/s41531-024-00715-0

Zocher, S., McCloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche, M., Rund, N., Gage, F.H., Hetzer, M.W., Toda, T. Lifelong persistence of nuclear RNAs in the mouse brain. (2024) Science. 384(6691):53-59. DOI: 10.1126/science.adf3481

Podvin, S., Jones, J., Kang, A., Goodman, R., Reed, P., Lietz, C.B., Then, J., Lee, K.C., Eyler, L.T., Jeste, D.V., Gage, F.H., Hook, V. Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. (2024) Molecular Psychiatry. DOI: 10.1038/s41380-024-02422-x

Toda, T., Bedrosian, T.A., Schafer, S.T., Cuoco, M.S., Linker, S.B., Ghassemzadeh, S., Mitchell, L., Whiteley, J.T., Novaresi, N., McDonald, A.H., Gallina, I.S., Yoon, H., Hester, M.E., Pena, M., Lim, C., Suljic, E., AlFatah Mansour, A., Boulard, M., Parylak, S.L., Gage, F.H. Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. (2024) Cell Reports. 43(2):113774. DOI: 10.1016/j.celrep.2024.113774

Rosh, I., Tripathi, U., Hussein, Y., Rike, W.A., Djamus, J., Shklyar, B., Manole, A., Houlden, H., Winkler, J., Gage, F.H., Stern, S. Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients. (2024) NPJ Parkinsons Dis. 10(1):38. DOI: 10.1038/s41531-024-00653-x

Wang, M., Zhang, L., Novak, S.W., Yu, J., Gallina, I.S., Xu, L.L., Lim, C.K., Fernandes, S., Shokhirev, M.N., Williams, A.E., Saxena, M.D., Coorapati, S., Parylak, S.L., Quintero, C., Molina, E., Andrade, L.R., Manor, U., Gage, F.H. Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. (2024) Nature Biotechnology. DOI: 10.1038/s41587-024-02157-8

Garrison, M.A., Jang, Y., Bae, T., Cherskov, A., Emery, S.B., Fasching, L., Jones, A., Moldovan, J.B., Molitor, C., Pochareddy, S., Peters, M.A., Shin, J.H., Wang, Y., Yang, X., Akbarian, S., Chess, A., Gage, F.H., Gleeson, J.G., Kidd, J.M., McConnell, M., Mills, R.E., Moran, J.V., Park, P.J., Sestan, N., Urban, A.E., Vaccarino, F.M., Walsh, C.A., Weinberger, D.R., Wheelan, S.J., Abyzov, A., . Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. (2023) Sci Data. 10(1):813. DOI: 10.1038/s41597-023-02645-7

Manole, A., Wong, T., Rhee, A., Novak, S., Chin, S.M., Tsimring, K., Paucar, A., Williams, A., Newmeyer, T.F., Schafer, S.T., Rosh, I., Kaushik, S., Hoffman, R., Chen, S., Wang, G., Snyder, M., Cuervo, A.M., Andrade, L., Manor, U., Lee, K., Jones, J.R., Stern, S., Marchetto, M.C., Gage, F.H. NGLY1 mutations cause protein aggregation in human neurons. (2023) Cell Reports. 42(12):113466. DOI: 10.1016/j.celrep.2023.113466

Mizrahi, L., Choudhary, A., Ofer, P., Goldberg, G., Milanesi, E., Kelsoe, J.R., Gurwitz, D., Alda, M., Gage, F.H., Stern, S. Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients. (2023) Molecular Psychiatry. DOI: 10.1038/s41380-023-02183-z

Traxler, L., Lucciola, R., Herdy, J.R., Jones, J.R., Mertens, J., Gage, F.H. Neural cell state shifts and fate loss in ageing and age-related diseases. (2023) Nat Rev Neurol. DOI: 10.1038/s41582-023-00815-0

Schafer, S.T., Mansour, A.A., Schlachetzki, J.C.M., Pena, M., Ghassemzadeh, S., Mitchell, L., Mar, A., Quang, D., Stumpf, S., Ortiz, I.S., Lana, A.J., Baek, C., Zaghal, R., Glass, C.K., Nimmerjahn, A., Gage, F.H. An in vivo neuroimmune organoid model to study human microglia phenotypes. (2023) Cell. 186(10):2111-2126.e20. DOI: 10.1016/j.cell.2023.04.022

Arlotta, P., Gage, F.H. Neural Organoids and the Quest to Understand and Treat Psychiatric Disease. (2023) Biological Psychiatry. 93(7):588-589. DOI: 10.1016/j.biopsych.2023.01.021

Mishra, H.K., Wei, H., Rohr, K.E., Ko, I., Nievergelt, C.M., Maihofer, A.X., Shilling, P.D., Alda, M., Berrettini, W.H., Brennand, K.J., Calabrese, J.R., Coryell, W.H., Frye, M., Gage, F., Gershon, E., McInnis, M.G., Nurnberger, J., Oedegaard, K.J., Zandi, P.P., Kelsoe, J.R., McCarthy, M.J. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. (2023) Eur Neuropsychopharmacol. 74:1-14. DOI: 10.1016/j.euroneuro.2023.04.009

Kempermann, G., Song, H., Gage, F.H. Adult neurogenesis in the hippocampus. (2023) Hippocampus. DOI: 10.1002/hipo.23525

Niemsiri, V., Rosenthal, S.B., Nievergelt, C.M., Maihofer, A.X., Marchetto, M.C., Santos, R., Shekhtman, T., Alliey-Rodriguez, N., Anand, A., Balaraman, Y., Berrettini, W.H., Bertram, H., Burdick, K.E., Calabrese, J.R., Calkin, C.V., Conroy, C., Coryell, W.H., DeModena, A., Eyler, L.T., Feeder, S., Fisher, C., Frazier, N., Frye, M.A., Gao, K., Garnham, J., Gershon, E.S., Goes, F.S., Goto, T., Harrington, G.J., Jakobsen, P., Kamali, M., Kelly, M., Leckband, S.G., Lohoff, F.W., McCarthy, M.J., McInnis, M.G., Craig, D., Millett, C.E., Mondimore, F., Morken, G., Nurnberger, J.I., Donovan, C.O., Øedegaard, K.J., Ryan, K., Schinagle, M., Shilling, P.D., Slaney, C., Stapp, E.K., Stautland, A., Tarwater, B., Zandi, P.P., Alda, M., Fisch, K.M., Gage, F.H., Kelsoe, J.R. Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. (2023) Molecular Psychiatry. DOI: 10.1038/s41380-022-01909-9

Parylak, S.L., Qiu, F., Linker, S.B., Gallina, I.S., Lim, C.K., Preciado, D., McDonald, A.H., Zhou, X., Gage, F.H. Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells. (2023) Hippocampus. DOI: 10.1002/hipo.23515

Bermperidis, T., Schafer, S., Gage, F.H., Sejnowski, T., Torres, E.B. Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders. (2023) Frontiers in Neuroscience. 16:884707. DOI: 10.3389/fnins.2022.884707

Perez-Garcia, G., Bicak, M., Haure-Mirande, J.V., Perez, G.M., Otero-Pagan, A., Gama Sosa, M.A., De Gasperi, R., Sano, M., Barlow, C., Gage, F.H., Readhead, B., Ehrlich, M.E., Gandy, S., Elder, G.A. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT mouse model of tauopathy. (2023) Neurosci Lett.:137080 DOI: 10.1016/j.neulet.2023.137080

Wang, M., Gage, F.H., Schafer, S.T. Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids. (2023) Biological Psychiatry. DOI: 10.1016/j.biopsych.2023.01.004

Herdy, J.R., Traxler, L., Agarwal, R.K., Karbacher, L., Schlachetzki, J.C.M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C.K., Mertens, J., Gage, F.H. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease. (2022) Cell Stem Cell. 29(12):1637-1652.e6. DOI: 10.1016/j.stem.2022.11.010

Fu, C., Ngo, J., Zhang, S., Lu, L., Miron, A., Schafer, S., Gage, F.H., Jin, F., Schumacher, F.R., Wynshaw-Boris, A. Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly. (2022) Human Molecular Genetics. DOI: 10.1093/hmg/ddac300

Wilson, M.N., Thunemann, M., Liu, X., Lu, Y., Puppo, F., Adams, J.W., Kim, J.H., Ramezani, M., Pizzo, D.P., Djurovic, S., Andreassen, O.A., Mansour, A.A., Gage, F.H., Muotri, A.R., Devor, A., Kuzum, D. Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. (2022) Nature Communications. 13(1):7945. DOI: 10.1038/s41467-022-35536-3

Linker, S.B., Narvaiza, I., Hsu, J.Y., Wang, M., Qiu, F., Mendes, A.P.D., Oefner, R., Kottilil, K., Sharma, A., Randolph-Moore, L., Mejia, E., Santos, R., Marchetto, M.C., Gage, F.H. Human-specific regulation of neural maturation identified by cross-primate transcriptomics. (2022) Current Biology. DOI: 10.1016/j.cub.2022.09.028

van den Hurk, M., Lau, S., Marchetto, M.C., Mertens, J., Stern, S., Corti, O., Brice, A., Winner, B., Winkler, J., Gage, F.H., Bardy, C. Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons. (2022) NPJ Parkinsons Dis. 8(1):134. DOI: 10.1038/s41531-022-00400-0

Pașca, S.P., Arlotta, P., Bateup, H.S., Camp, J.G., Cappello, S., Gage, F.H., Knoblich, J.A., Kriegstein, A.R., Lancaster, M.A., Ming, G.L., Muotri, A.R., Park, I.H., Reiner, O., Song, H., Studer, L., Temple, S., Testa, G., Treutlein, B., Vaccarino, F.M. A nomenclature consensus for nervous system organoids and assembloids. (2022) Nature. 609(7929):907-910. DOI: 10.1038/s41586-022-05219-6

Stern, S., Lau, S., Manole, A., Rosh, I., Percia, M.M., Ben Ezer, R., Shokhirev, M.N., Qiu, F., Schafer, S., Mansour, A.A., Mangan, K.P., Stern, T., Ofer, P., Stern, Y., Diniz Mendes, A.P., Djamus, J., Moore, L.R., Nayak, R., Laufer, S.H., Aicher, A., Rhee, A., Wong, T.L., Nguyen, T., Linker, S.B., Winner, B., Freitas, B.C., Jones, E., Sagi, I., Bardy, C., Brice, A., Winkler, J., Marchetto, M.C., Gage, F.H. Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients. (2022) NPJ Parkinsons Dis. 8(1):103. DOI: 10.1038/s41531-022-00366-z

Traxler, L., Herdy, J.R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R.K., Schlachetzki, J.C.M., Glass, C.K., Lagerwall, J., Galasko, D., Gage, F.H., D’Alessandro, A., Mertens, J. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease. (2022) Cell Metabolism. DOI: 10.1016/j.cmet.2022.07.014

van Niekerk, E.A., Kawaguchi, R., Marques de Freria, C., Groeniger, K., Marchetto, M.C., Dupraz, S., Bradke, F., Geschwind, D.H., Gage, F.H., Tuszynski, M.H. Methods for culturing adult CNS neurons reveal a CNS conditioning effect. (2022) Cell Rep Methods. 2(7):100255. DOI: 10.1016/j.crmeth.2022.100255

Bae, T., Fasching, L., Wang, Y., Shin, J.H., Suvakov, M., Jang, Y., Norton, S., Dias, C., Mariani, J., Jourdon, A., Wu, F., Panda, A., Pattni, R., Chahine, Y., Yeh, R., Roberts, R.C., Huttner, A., Kleinman, J.E., Hyde, T.M., Straub, R.E., Walsh, C.A., ., Urban, A.E., Leckman, J.F., Weinberger, D.R., Vaccarino, F.M., Abyzov, A., Walsh, C.A., Park, P.J., Sestan, N., Weinberger, D., Moran, J.V., Gage, F.H., Vaccarino, F.M., Gleeson, J., Mathern, G., Courchesne, E., Roy, S., Chess, A.J., Akbarian, S., Bizzotto, S., Coulter, M., Dias, C., D’Gama, A., Ganz, J., Hill, R., Huang, A.Y., Khoshkhoo, S., Kim, S., Lee, A., Lodato, M., Maury, E.A., Miller, M., Borges-Monroy, R., Rodin, R., Zhou, Z., Bohrson, C., Chu, C., Cortes-Ciriano, I., Dou, Y., Galor, A., Gulhan, D., Kwon, M., Luquette, J., Sherman, M., Viswanadham, V., Jones, A., Rosenbluh, C., Cho, S., Langmead, B., Thorpe, J., Erwin, J., Jaffe, A., McConnell, M., Narurkar, R., Paquola, A., Shin, J., Straub, R., Abyzov, A., Bae, T., Jang, Y., Wang, Y., Molitor, C., Peters, M., Linker, S., Reed, P., Wang, M., Urban, A., Zhou, B., Zhu, X., Pattni, R., Serres Amero, A., Juan, D., Lobon, I., Marques-Bonet, T., Solis Moruno, M., Garcia Perez, R., Povolotskaya, I., Soriano, E., Antaki, D., Averbuj, D., Ball, L., Breuss, M., Yang, X., Chung, C., Emery, S.B., Flasch, D.A., Kidd, J.M., Kopera, H.C., Kwan, K.Y., Mills, R.E., Moldovan, J.B., Sun, C., Zhao, X., Zhou, W., Frisbie, T.J., Cherskov, A., Fasching, L., Jourdon, A., Pochareddy, S., Scuderi, S. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. (2022) Science. 377(6605):511-517. DOI: 10.1126/science.abm6222

Shi, Y., Evans, R.M., Gage, F.H. Oleic acid regulates hippocampal neurogenesis as a TLX ligand. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(15):e2203038119. DOI: 10.1073/pnas.2203038119

Gage, F.H. Adult neurogenesis in neurological diseases. (2021) Science. 374(6571):1049-1050. DOI: 10.1126/science.abm7468

Heard, K.J., Shokhirev, M.N., Becronis, C., Fredlender, C., Zahid, N., Le, A.T., Ji, Y., Skime, M., Nelson, T., Hall-Flavin, D., Weinshilboum, R., Gage, F.H., Vadodaria, K.C. Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. (2021) Transl Psychiatry. 11(1):608. DOI: 10.1038/s41398-021-01733-9

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J.D., Linker, S.B., Gage, F.H., Kreiling, J.A., Petrashen, A.P., Woodham, T.A., Taylor, J.R., Helfand, S.L., Sedivy, J.M. The role of retrotransposable elements in ageing and age-associated diseases. https://rdcu.be/ct1i3 Full-text provided by the Springer Nature SharedIt content-sharing initiative (2021) Nature. 596(7870):43-53. DOI: 10.1038/s41586-021-03542-y

Shadel, G.S., Adams, P.D., Berggren, W.T., Diedrich, J.K., Diffenderfer, K.E., Gage, F.H., Hah, N., Hansen, M., Hetzer, M.W., Molina, A.J.A., Manor, U., Marek, K., O’Keefe, D.D., Pinto, A.F.M., Sacco, A., Sharpee, T.O., Shokriev, M.N., Zambetti, S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. (2021) Geroscience. DOI: 10.1007/s11357-021-00426-x

Johnston, S., Parylak, S., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C.D., Novak, O., Goncalves, J.T., Gage, F.H., Shtrahman, M. AAV ablates neurogenesis in the adult murine hippocampus. (2021) Elife. 10. DOI: 10.7554/eLife.59291

Tan, K., Kim, M.E., Song, H.W., Skarbrevik, D., Babajanian, E., Bedrosian, T.A., Gage, F.H., Wilkinson, M.F. The Rhox gene cluster suppresses germline LINE1 transposition. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(23). DOI: 10.1073/pnas.2024785118

Schafer, S.T., Gage, F.H. To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(19). DOI: 10.1073/pnas.2104888118

Dias, G.P., Murphy, T., Stangl, D., Ahmet, S., Morisse, B., Nix, A., Aimone, L.J., Aimone, J.B., Kuro-O, M., Gage, F.H., Thuret, S. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01102-4

Reid, D.A., Reed, P.J., Schlachetzki, J.C.M., Nitulescu, I.I., Chou, G., Tsui., Chandran, S., Jones, J.R., Lu, A.T., McClain, C.A., Ooi, J.H., Wang, T.W., Lana., Linker, S.B., Ricciardulli, A.S., Lau, S., Schafer, S., Horvath, S., Dixon, J.R., Hah, N., Glass, C.K., Gage, F.H. Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. (2021) Science. 372(6537):91-94. DOI: 10.1126/science.abb9032

Mertens, J., Herdy, J.R., Traxler, L., Schafer, S.T., Schlachetzki, J.C.M., Böhnke, L., Reid, D.A., Lee, H., Zangwill, D., Fernandes, D.P., Agarwal, R.K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A.C.M., Glass, C.K., Yuan, S.H., Ku, M., Szücs, A., Goldstein, L.S.B., Galasko, D., Gage, F.H. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients. (2021) Cell Stem Cell. DOI: 10.1016/j.stem.2021.04.004

Schafer, S.T., Gage, F.H. The When and Where: Molecular and Cellular Convergence in Autism. (2021) Biological Psychiatry. 89(5):419-420. DOI: 10.1016/j.biopsych.2020.12.016

Mishra, H.K., Ying, N.M., Luis, A., Wei, H., Nguyen, M., Nakhla, T., Vandenburgh, S., Alda, M., Berrettini, W.H., Brennand, K.J., Calabrese, J.R., Coryell, W.H., Frye, M.A., Gage, F.H., Gershon, E.S., McInnis, M.G., Nievergelt, C.M., Nurnberger, J.I., Shilling, P.D., Oedegaard, K.J., Zandi, P.P., ., Kelsoe, J.R., Welsh, D.K., McCarthy, M.J. Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01048-7

Nakatsuka, N., Heard, K.J., Faillétaz, A., Momotenko, D., Vörös, J., Gage, F.H., Vadodaria, K.C. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01066-5

Bedrosian, T.A., Houtman, J., Eguiguren, J.S., Ghassemzadeh, S., Rund, N., Novaresi, N.M., Hu, L., Parylak, S.L., Denli, A.M., Randolph-Moore, L., Namba, T., Gage, F.H., Toda, T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. (2021) EMBO Journal. 40(3):e105819. DOI: 10.15252/embj.2020105819

Fukuda, S., Varshney, A., Fowler, B.J., Wang, S.B., Narendran, S., Ambati, K., Yasuma, T., Magagnoli, J., Leung, H., Hirahara, S., Nagasaka, Y., Yasuma, R., Apicella, I., Pereira, F., Makin, R.D., Magner, E., Liu, X., Sun, J., Wang, M., Baker, K., Marion, K.M., Huang, X., Baghdasaryan, E., Ambati, M., Ambati, V.L., Pandey, A., Pandya, L., Cummings, T., Banerjee, D., Huang, P., Yerramothu, P., Tolstonog, G.V., Held, U., Erwin, J.A., Paquola, A.C.M., Herdy, J.R., Ogura, Y., Terasaki, H., Oshika, T., Darwish, S., Singh, R.K., Mozaffari, S., Bhattarai, D., Kim, K.B., Hardin, J.W., Bennett, C.L., Hinton, D.R., Hanson, T.E., Röver, C., Parang, K., Kerur, N., Liu, J., Werner, B.C., Sutton, S.S., Sadda, S.R., Schumann, G.G., Gelfand, B.D., Gage, F.H., Ambati, J. Cytoplasmic synthesis of endogenous complementary DNA via reverse transcription and implications in age-related macular degeneration. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(6). DOI: 10.1073/pnas.2022751118

Vadodaria, K.C., Mendes, A.P.D., Mei, A., Racha, V., Erikson, G., Shokhirev, M.N., Oefner, R., Heard, K.J., McCarthy, M.J., Eyler, L., Kelsoe, J.R., Santos, R., Marchetto, M.C., Gage, F.H. Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. (2021) Stem Cell Reports. DOI: 10.1016/j.stemcr.2021.02.004

Santos, R., Linker, S.B., Stern, S., Mendes, A.P.D., Shokhirev, M.N., Erikson, G., Randolph-Moore, L., Racha, V., Kim, Y., Kelsoe, J.R., Bang, A.G., Alda, M., Marchetto, M.C., Gage, F.H. Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-020-00981-3

Wang, Q.W., Lu, S.Y., Liu, Y.N., Chen, Y., Wei, H., Shen, W., Chen, Y.F., Fu, C.L., Wang, Y.H., Dai, A., Huang, X., Gage, F.H., Xu, Q., Yao, J. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.2016416117

Linker, S.B., Randolph-Moore, L., Kottilil, K., Qiu, F., Jaeger, B.N., Barron, J., Gage, F.H. Identification of bona fide B2 SINE retrotransposon transcription through single-nucleus RNA-seq of the mouse hippocampus. (2020) Genome Research. DOI: 10.1101/gr.262196.120

Figueiredo, T., Mendes, A.P.D., Moreira, D.P., Goulart, E., Oliveira, D., Kobayashi, G.S., Stern, S., Kok, F., Marchetto, M.C., Santos, R., Gage, F.H., Zatz, M. Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. (2020) Molecular Psychiatry. DOI: 10.1038/s41380-020-00862-9

Kerman, B.E., Genoud, S., Kurt Vatandaslar, B., Denli, A.M., Ghosh, S.G., Xu, X., Yeo, G.W., Aimone, J.B., Gage, F.H. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. (2020) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA120.014329

Mansour, A.A., Schafer, S.T., Gage, F.H. Cellular complexity in brain organoids: Current progress and unsolved issues. (2020) Seminars in Cell & Developmental Biology. DOI: 10.1016/j.semcdb.2020.05.013

Wenderski, W., Wang, L., Krokhotin, A., Walsh, J.J., Li, H., Shoji, H., Ghosh, S., George, R.D., Miller, E.L., Elias, L., Gillespie, M.A., Son, E.Y., Staahl, B.T., Baek, S.T., Stanley, V., Moncada, C., Shipony, Z., Linker, S.B., Marchetto, M.C.N., Gage, F.H., Chen, D., Sultan, T., Zaki, M.S., Ranish, J.A., Miyakawa, T., Luo, L., Malenka, R.C., Crabtree, G.R., Gleeson, J.G. Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1908238117

Sun, G., Chiuppesi, F., Chen, X., Wang, C., Tian, E., Nguyen, J., Kha, M., Trinh, D., Zhang, H., Marchetto, M.C., Song, H., Ming, G.L., Gage, F.H., Diamond, D.J., Wussow, F., Shi, Y. Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. (2020) Cell Reports Medicine. 1(1):100002. DOI: 10.1016/j.xcrm.2020.100002

Shen, W., Wang, Q.W., Liu, Y.N., Marchetto, M.C., Linker, S., Lu, S.Y., Chen, Y., Liu, C., Guo, C., Xing, Z., Shi, W., Kelsoe, J.R., Alda, M., Wang, H., Zhong, Y., Sui, S.F., Zhao, M., Yang, Y., Mi, S., Cao, L., Gage, F.H., Yao, J. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1918165117

Stern, S., Sarkar, A., Galor, D., Stern, T., Mei, A., Stern, Y., Mendes, A.P.D., Randolph-Moore, L., Rouleau, G., Bang, A.G., Santos, R., Alda, M., Marchetto, M.C., Gage, F.H. A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients. (2020) Biological Psychiatry. DOI: 10.1016/j.biopsych.2020.01.020

Wang, M., Wei, P.C., Lim, C.K., Gallina, I.S., Marshall, S., Marchetto, M.C., Alt, F.W., Gage, F.H. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. (2020) Cell Stem Cell. 26(2):221-233.e6 . DOI: 10.1016/j.stem.2019.12.013

Zhu, Z., Mesci, P., Bernatchez, J.A., Gimple, R.C., Wang, X., Schafer, S.T., Wettersten, H.I., Beck, S., Clark, A.E., Wu, Q., Prager, B.C., Kim, L.J.Y., Dhanwani, R., Sharma, S., Garancher, A., Weis, S.M., Mack, S.C., Negraes, P.D., Trujillo, C.A., Penalva, L.O., Feng, J., Lan, Z., Zhang, R., Wessel, A.W., Dhawan, S., Diamond, M.S., Chen, C.C., Wechsler-Reya, R.J., Gage, F.H., Hu, H., Siqueira-Neto, J.L., Muotri, A.R., Cheresh, D.A., Rich, J.N. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αβ Axis. (2019) Cell Stem Cell. 26(2):187-204. DOI: 10.1016/j.stem.2019.11.016

Nott, A., Holtman, I.R., Coufal, N.G., Schlachetzki, J.C.M., Yu, M., Hu, R., Han, C.Z., Pena, M., Xiao, J., Wu, Y., Keulen, Z., Pasillas, M.P., O’Connor, C., Nickl, C.K., Schafer, S.T., Shen, Z., Rissman, R.A., Brewer, J.B., Gosselin, D., Gonda, D.D., Levy, M.L., Rosenfeld, M.G., McVicker, G., Gage, F.H., Ren, B., Glass, C.K. Brain cell type-specific enhancer-promoter interactome maps and disease risk association. (2019) Science. 366(6469):1134-1139. DOI: 10.1126/science.aay0793

Vadodaria, K.C., Jones, J.R., Linker, S., Gage, F.H. Modeling Brain Disorders Using Induced Pluripotent Stem Cells. (2019) Cold Spring Harbor Perspectives in Biology. DOI: 10.1101/cshperspect.a035659

Stern, S., Sarkar, A., Stern, T., Mei, A., Mendes, A.P.D., Stern, Y., Goldberg, G., Galor, D., Nguyen, T., Randolph-Moore, L., Kim, Y., Rouleau, G., Bang, A., Alda, M., Santos, R., Marchetto, M.C., Gage, F.H. Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder. (2019) Biological Psychiatry. DOI: 10.1016/j.biopsych.2019.09.018

Amatya, D.N., Linker, S.B., Mendes, A.P.D., Santos, R., Erikson, G., Shokhirev, M.N., Zhou, Y., Sharpee, T., Gage, F.H., Marchetto, M.C., Kim, Y. Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. (2019) Stem Cell Reports. DOI: 10.1016/j.stemcr.2019.08.001

Quraishi, I.H., Stern, S., Mangan, K.P., Zhang, Y., Ali, S.R., Mercier, M.R., Marchetto, M.C., McLachlan, M.J., Jones, E.M., Gage, F.H., Kaczmarek, L.K. An epilepsy-associated KCNT1 mutation enhances excitability of human iPSC-derived neurons by increasing Slack K currents. (2019) Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.1628-18.2019

Stern, S., Linker, S., Vadodaria, K.C., Marchetto, M.C., Gage, F.H. Prediction of Response to Drug Therapy in Psychiatric Disorders. (2019) Focus (American Psychiatric Publishing). 17(3):294-307. DOI: 10.1176/appi.focus.17304

Vadodaria, K.C., Ji, Y., Skime, M., Paquola, A., Nelson, T., Hall-Flavin, D., Fredlender, C., Heard, K.J., Deng, Y., Le, A.T., Dave, S., Fung, L., Li, X., Marchetto, M.C., Weinshilboum, R., Gage, F.H. Studying treatment resistance in depression using patient derived neurons in vitro. (2019) Molecular Psychiatry. 24(6):775. DOI: 10.1038/s41380-019-0424-2

Sommer, A., Marxreiter, F., Krach, F., Fadler, T., Grosch, J., Maroni, M., Graef, D., Eberhardt, E., Riemenschneider, M.J., Yeo, G.W., Kohl, Z., Xiang, W., Gage, F.H., Winkler, J., Prots, I., Winner, B. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease. (2019) Cell Stem Cell. 24(6):1006. DOI: 10.1016/j.stem.2019.04.019

Herdy, J., Schafer, S., Kim, Y., Ansari, Z., Zangwill, D., Ku, M., Paquola, A., Lee, H., Mertens, J., Gage, F.H. Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. (2019) Elife. 8. DOI: 10.7554/eLife.41356

Wang, M., Zhang, L., Gage, F.H. Modeling neuropsychiatric disorders using human induced pluripotent stem cells. (2019) Protein & Cell. 11(1):45-59. DOI: 10.1007/s13238-019-0638-8

Schafer, S.T., Gage, F.H. Nerve cells from the brain invade prostate tumours. (2019) Nature. 569(7758):637-638. DOI: 10.1038/d41586-019-01461-7

Gage, F.H. Adult neurogenesis in mammals. (2019) Science. 364(6443):827-828. DOI: 10.1126/science.aav6885

Nudell, V., Wei, H., Nievergelt, C., Maihofer, A.X., Shilling, P., Alda, M., Berrettini, W.H., Brennand, K.J., Calabrese, J.R., Coryell, W.H., Covault, J.M., Frye, M.A., Gage, F., Gershon, E., McInnis, M.G., Nurnberger, J.I., Oedegaard, K.J., Shekhtman, T., Zandi, P.P., Kelsoe, J.R., McCarthy, M.J. Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. (2019) Molecular Neuropsychiatry. 5(2):115-124. DOI: 10.1159/000497354

Wang, M., Zhang, L., Gage, F.H. Microglia, complement and schizophrenia. (2019) Nature Neuroscience. 22(3):333-334. DOI: 10.1038/s41593-019-0343-1

Farrelly, L.A., Thompson, R.E., Zhao, S., Lepack, A.E., Lyu, Y., Bhanu, N.V., Zhang, B., Loh, Y.E., Ramakrishnan, A., Vadodaria, K.C., Heard, K.J., Erikson, G., Nakadai, T., Bastle, R.M., Lukasak, B.J., Zebroski, H., Alenina, N., Bader, M., Berton, O., Roeder, R.G., Molina, H., Gage, F.H., Shen, L., Garcia, B.A., Li, H., Muir, T.W., Maze, I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. (2019) Nature. DOI: 10.1038/s41586-019-1024-7

Vadodaria, K.C., Ji, Y., Skime, M., Paquola, A.C., Nelson, T., Hall-Flavin, D., Heard, K.J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A.T., Marchetto, M.C., Weinshilboum, R., Gage, F.H. Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. (2019) Molecular Psychiatry. DOI: 10.1038/s41380-019-0377-5

Marchetto, M.C., Hrvoj-Mihic, B., Kerman, B.E., Yu, D.X., Vadodaria, K.C., Linker, S.B., Narvaiza, I., Santos, R., Denli, A.M., Mendes, A.P., Oefner, R., Cook, J., McHenry, L., Grasmick, J.M., Heard, K., Fredlender, C., Randolph-Moore, L., Kshirsagar, R., Xenitopoulos, R., Chou, G., Hah, N., Muotri, A.R., Padmanabhan, K., Semendeferi, K., Gage, F.H. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. (2019) Elife. 8. DOI: 10.7554/eLife.37527

Lucassen, P.J., Toni, N., Kempermann, G., Frisen, J., Gage, F.H., Swaab, D.F. Limits to human neurogenesis-really? (2019) Molecular Psychiatry. DOI: 10.1038/s41380-018-0337-5

Schafer, S.T., Paquola, A.C.M., Stern, S., Gosselin, D., Ku, M., Pena, M., Kuret, T.J.M., Liyanage, M., Mansour, A.A., Jaeger, B.N., Marchetto, M.C., Glass, C.K., Mertens, J., Gage, F.H. Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. (2019) Nature Neuroscience. DOI: 10.1038/s41593-018-0295-x

Eftekharzadeh, B., Daigle, J.G., Kapinos, L.E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S.J., Dujardin, S., Amaral, A.S., Grima, J.C., Bennett, R.E., Tepper, K., DeTure, M., Vanderburg, C.R., Corjuc, B.T., DeVos, S.L., Gonzalez, J.A., Chew, J., Vidensky, S., Gage, F.H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R.Y.H., Petrucelli, L., Wegmann, S., Rothstein, J.D., Hyman, B.T. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease. (2019) Neuron. 101(2):349. DOI: 10.1016/j.neuron.2018.12.031

Padmanabhan, K., Osakada, F., Tarabrina, A., Kizer, E., Callaway, E.M., Gage, F.H., Sejnowski, T.J. Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping. (2019) Frontiers in Neuroanatomy. 12:115. DOI: 10.3389/fnana.2018.00115

Vadodaria, K.C., Ji, Y., Skime, M., Paquola, A., Nelson, T., Hall-Flavin, D., Fredlender, C., Heard, K.J., Deng, Y., Le, A.T., Dave, S., Fung, L., Li, X., Marchetto, M.C., Weinshilboum, R., Gage, F.H. Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. (2019) Molecular Psychiatry. DOI: 10.1038/s41380-019-0363-y

Kim, Y., Vadodaria, K.C., Lenkei, Z., Kato, T., Gage, F.H., Marchetto, M.C., Santos, R. MITOCHONDRIA, METABOLISM AND REDOX MECHANISMS IN PSYCHIATRIC DISORDERS. (2018) Antioxidants & Redox Signaling. DOI: 10.1089/ars.2018.7606

McCarthy, M.J., Wei, H., Nievergelt, C.M., Stautland, A., Maihofer, A.X., Welsh, D.K., Shilling, P., Alda, M., Alliey-Rodriguez, N., Anand, A., Andreasson, O.A., Balaraman, Y., Berrettini, W.H., Bertram, H., Brennand, K.J., Calabrese, J.R., Calkin, C.V., Claasen, A., Conroy, C., Coryell, W.H., Craig, D.W., D’Arcangelo, N., Demodena, A., Djurovic, S., Feeder, S., Fisher, C., Frazier, N., Frye, M.A., Gage, F.H., Gao, K., Garnham, J., Gershon, E.S., Glazer, K., Goes, F., Goto, T., Harrington, G., Jakobsen, P., Kamali, M., Karberg, E., Kelly, M., Leckband, S.G., Lohoff, F., McInnis, M.G., Mondimore, F., Morken, G., Nurnberger, J.I., Obral, S., Oedegaard, K.J., Ortiz, A., Ritchey, M., Ryan, K., Schinagle, M., Schoeyen, H., Schwebel, C., Shaw, M., Shekhtman, T., Slaney, C., Stapp, E., Szelinger, S., Tarwater, B., Zandi, P.P., Kelsoe, J.R. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. (2018) Neuropsychopharmacology . DOI: 10.1038/s41386-018-0273-8

Suh, H., Zhou, Q.G., Fernandez-Carasa, I., Clemenson, G.D., Pons-Espinal, M., Ro, E.J., Marti, M., Raya, A., Gage, F.H., Consiglio, A. Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector. (2018) Frontiers in Molecular Neuroscience. 11:415. DOI: 10.3389/fnmol.2018.00415

Kuhn, H.G., Toda, T., Gage, F.H. Adult hippocampal neurogenesis: a coming-of-age story. (2018) Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.2144-18.2018

Eftekharzadeh, B., Daigle, J.G., Kapinos, L.E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S.J., Dujardin, S., Amaral, A.S., Grima, J.C., Bennett, R.E., Tepper, K., DeTure, M., Vanderburgh, C.R., Corjuc, B.T., DeVos, S.L., Gonzalez, J.A., Chew, J., Vidensky, S., Gage, F.H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R.Y.H., Petrucelli, L., Wegmann, S., Rothstein, J.D., Hyman, B.T. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease. (2018) Neuron. 99(5):925-940.e7. DOI: 10.1016/j.neuron.2018.07.039

Choi, S.H., Bylykbashi, E., Chatila, Z.K., Lee, S.W., Pulli, B., Clemenson, G.D., Kim, E., Rompala, A., Oram, M.K., Asselin, C., Aronson, J., Zhang, C., Miller, S.J., Lesinski, A., Chen, J.W., Kim, D.Y., van Praag, H., Spiegelman, B.M., Gage, F.H., Tanzi, R.E. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. (2018) Science. 361(6406). DOI: 10.1126/science.aan8821

Mertens, J., Reid, D., Lau, S., Kim, Y., Gage, F.H. Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. (2018) Annual Review of Genetics. 52:271-293. DOI: 10.1146/annurev-genet-120417-031534

Jaeger, B.N., Linker, S.B., Parylak, S.L., Barron, J.J., Gallina, I.S., Saavedra, C.D., Fitzpatrick, C., Lim, C.K., Schafer, S.T., Lacar, B., Jessberger, S., Gage, F.H. A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. (2018) Nature Communications. 9(1):3084. DOI: 10.1038/s41467-018-05418-8

van den Hurk, M., Erwin, J.A., Yeo, G.W., Gage, F.H., Bardy, C. Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. (2018) Frontiers in Molecular Neuroscience. 11:261. DOI: 10.3389/fnmol.2018.00261

Sommer, A., Maxreiter, F., Krach, F., Fadler, T., Grosch, J., Maroni, M., Graef, D., Eberhardt, E., Riemenschneider, M.J., Yeo, G.W., Kohl, Z., Xiang, W., Gage, F.H., Winkler, J., Prots, I., Winner, B. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease. (2018) Cell Stem Cell. 23(1):123-131.e6. DOI: 10.1016/j.stem.2018.06.015

Linker, S.B., Hsu, J.Y., Pfaff, A., Amatya, D., Ko, S.M., Voter, S., Wong, Q., Gage, F.H. BrainImageR: Spatiotemporal gene set analysis referencing the human brain. (2018) Bioinformatics. DOI: 10.1093/bioinformatics/bty618

Kronenberg, Z.N., Fiddes, I.T., Gordon, D., Murali, S., Cantsilieris, S., Meyerson, O.S., Underwood, J.G., Nelson, B.J., Chaisson, M.J.P., Dougherty, M.L., Munson, K.M., Hastie, A.R., Diekhans, M., Hormozdiari, F., Lorusso, N., Hoekzema, K., Qiu, R., Clark, K., Raja, A., Welch, A.E., Sorensen, M., Baker, C., Fulton, R.S., Armstrong, J., Graves-Lindsay, T.A., Denli, A.M., Hoppe, E.R., Hsieh, P., Hill, C.M., Pang, A.W.C., Lee, J., Lam, E.T., Dutcher, S.K., Gage, F.H., Warren, W.C., Shendure, J., Haussler, D., Schneider, V.A., Cao, H., Ventura, M., Wilson, R.K., Paten, B., Pollen, A., Eichler, E.E. High-resolution comparative analysis of great ape genomes. (2018) Science. 360(6393). DOI: 10.1126/science.aar6343

Sarkar, A., Mei, A., Paquola, A.C.M., Stern, S., Bardy, C., Klug, J.R., Kim, S., Neshat, N., Kim, H.J., Ku, M., Shokhirev, M.N., Adamowicz, D.H., Marchetto, M.C., Jappelli, R., Erwin, J.A., Padmanabhan, K., Shtrahman, M., Jin, X., Gage, F.H. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. (2018) Cell Stem Cell. 22(5):684-697.e9. DOI: 10.1016/j.stem.2018.04.009

Strnadel, J., Carromeu, C., Bardy, C., Navarro, M., Platoshyn, O., Glud, A.N., Marsala, S., Kafka, J., Miyanohara, A., Kato, T., Tadokoro, T., Hefferan, M.P., Kamizato, K., Yoshizumi, T., Juhas, S., Juhasova, J., Ho, C.S., Kheradmand, T., Chen, P., Bohaciakova, D., Hruska-Plochan, M., Todd, A.J., Driscoll, S.P., Glenn, T.D., Pfaff, S.L., Klima, J., Ciacci, J., Curtis, E., Gage, F.H., Bui, J., Yamada, K., Muotri, A.R., Marsala, M. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. (2018) Science Translational Medicine. 10(440). DOI: 10.1126/scitranslmed.aam6651

Stern, S., Linker, S., Vadodaria, K.C., Marchetto, M.C., Gage, F.H. Prediction of response to drug therapy in psychiatric disorders. (2018) Open Biology. 8(5). DOI: 10.1098/rsob.180031

Kim, Y., Zheng, X., Ansari, Z., Bunnell, M.C., Herdy, J.R., Traxler, L., Lee, H., Paquola, A.C.M., Blithikioti, C., Ku, M., Schlachetzki, J.C.M., Winkler, J., Edenhofer, F., Glass, C.K., Paucar, A.A., Jaeger, B.N., Pham, S., Boyer, L., Campbell, B.C., Hunter, T., Mertens, J., Gage, F.H. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. (2018) Cell Reports. 23(9):2550-2558. DOI: 10.1016/j.celrep.2018.04.105

Mansour, A.A., Gonçalves, J.T., Bloyd, C.W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S.L., Jin, X., Gage, F.H. An in vivo model of functional and vascularized human brain organoids. (2018) Nature Biotechnology. DOI: 10.1038/nbt.4127

Toda, T., Parylak, S.L., Linker, S.B., Gage, F.H. The role of adult hippocampal neurogenesis in brain health and disease. (2018) Molecular Psychiatry. DOI: 10.1038/s41380-018-0036-2

Kempermann, G., Gage, F.H., Aigner, L., Song, H., Curtis, M.A., Thuret, S., Kuhn, H.G., Jessberger, S., Frankland, P.W., Cameron, H.A., Gould, E., Hen, R., Abrous, D.N., Toni, N., Schinder, A.F., Zhao, X., Lucassen, P.J., Frisén, J. Human Adult Neurogenesis: Evidence and Remaining Questions. (2018) Cell Stem Cell. DOI: 10.1016/j.stem.2018.04.004

Bedrosian, T.A., Quayle, C., Novaresi, N., Gage, F.H. Early life experience drives structural variation of neural genomes in mice. (2018) Science. 359(6382):1395-1399. DOI: 10.1126/science.aah3378

Zheng, Y., Shen, W., Zhang, J., Yang, B., Liu, Y.N., Qi, H., Yu, X., Lu, S.Y., Chen, Y., Xu, Y.Z., Li, Y., Gage, F.H., Mi, S., Yao, J. CRISPR interference-based specific and efficient gene inactivation in the brain. (2018) Nature Neuroscience. DOI: 10.1038/s41593-018-0077-5

Vadodaria, K.C., Amatya, D.N., Marchetto, M.C., Gage, F.H. Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. (2018) Genome Medicine. 10(1):1. DOI: 10.1186/s13073-017-0512-3

Jaeger, B.N., Parylak, S.L., Gage, F.H. Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. (2017) Molecular Aspects of Medicine. DOI: 10.1016/j.mam.2017.11.003

Toda, T., Gage, F.H. Review: adult neurogenesis contributes to hippocampal plasticity. (2017) Cell and Tissue Research. DOI: 10.1007/s00441-017-2735-4

Snijders, C., de Nijs, L., Baker, D.G., Hauger, R.L., van den Hove, D., Kenis, G., Nievergelt, C.M., Boks, M.P., Vermetten, E., Gage, F.H., Rutten, B.P.F. MicroRNAs in Post-traumatic Stress Disorder. (2017) Current Topics in Behavioral Neurosciences. DOI: 10.1007/7854_2017_32

Topol, A., Zhu, S., Hartley, B.J., English, J., Hauberg, M.E., Tran, N., Rittenhouse, C.A., Simone, A., Ruderfer, D.M., Johnson, J., Readhead, B., Hadas, Y., Gochman, P.A., Wang, Y.C., Shah, H., Cagney, G., Rapoport, J., Gage, F.H., Dudley, J.T., Sklar, P., Mattheisen, M., Cotter, D., Fang, G., Brennand, K.J. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. (2017) Cell Reports. 20(10):2525. DOI: 10.1016/j.celrep.2017.08.073

Toda, T., Hsu, J.Y., Linker, S.B., Hu, L., Schafer, S.T., Mertens, J., Jacinto, F.V., Hetzer, M.W., Gage, F.H. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. (2017) Cell Stem Cell. 21:618–634. DOI: 10.1016/j.stem.2017.08.012

Shahsavani, M., Pronk, R.J., Falk, R., Lam, M., Moslem, M., Linker, S.B., Salma, J., Day, K., Schuster, J., Anderlid, B.M., Dahl, N., Gage, F.H., Falk, A. An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. (2017) Molecular Psychiatry. DOI: 10.1038/mp.2017.175

Vadodaria, K.C., Stern, S., Marchetto, M.C., Gage, F.H. Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. (2017) Cell and Tissue Research. DOI: 10.1007/s00441-017-2670-4

Linker, S.B., Marchetto, M.C., Narvaiza, I., Denli, A.M., Gage, F.H. Examining non-LTR retrotransposons in the context of the evolving primate brain. (2017) BMC Biology. 15(1):68. DOI: 10.1186/s12915-017-0409-z

Newkirk, S.J., Lee, S., Grandi, F.C., Gaysinskaya, V., Rosser, J.M., Vanden Berg, N., Hogarth, C.A., Marchetto, M.C.N., Muotri, A.R., Griswold, M.D., Ye, P., Bortvin, A., Gage, F.H., Boeke, J.D., An, W. Intact piRNA pathway prevents L1 mobilization in male meiosis. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(28):E5635-E5644. DOI: 10.1073/pnas.1701069114

Santos, R., Vadodaria, K.C., Jaeger, B.N., Mei, A., Lefcochilos-Fogelquist, S., Mendes, A.P.D., Erikson, G., Shokhirev, M., Randolph-Moore, L., Fredlender, C., Dave, S., Oefner, R., Fitzpatrick, C., Pena, M., Barron, J.J., Ku, M., Denli, A.M., Kerman, B.E., Charnay, P., Kelsoe, J.R., Marchetto, M.C., Gage, F.H. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. (2017) Stem Cell Reports. 8(6):1757-1769. DOI: 10.1016/j.stemcr.2017.05.011

Gosselin, D., Skola, D., Coufal, N.G., Holtman, I.R., Schlachetzki, J.C.M., Sajti, E., Jaeger, B.N., O’Connor, C., Fitzpatrick, C., Pasillas, M.P., Pena, M., Adair, A., Gonda, D.D., Levy, M.L., Ransohoff, R.M., Gage, F.H., Glass, C.K. An environment-dependent transcriptional network specifies human microglia identity. (2017) Science. 356(6344). DOI: 10.1126/science.aal3222

Marchetto, M.C., Belinson, H., Tian, Y., Freitas, B.C., Fu, C., Vadodaria, K., Beltrao-Braga, P., Trujillo, C.A., Mendes, A.P.D., Padmanabhan, K., Nunez, Y., Ou, J., Ghosh, H., Wright, R., Brennand, K., Pierce, K., Eichenfield, L., Pramparo, T., Eyler, L., Barnes, C.C., Courchesne, E., Geschwind, D.H., Gage, F.H., Wynshaw-Boris, A., Muotri, A.R. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. (2017) Molecular Psychiatry. 22(6):820-835. DOI: 10.1038/mp.2016.95

Ishii, S., Torii, M., Son, A.I., Rajendraprasad, M., Morozov, Y.M., Kawasawa, Y.I., Salzberg, A.C., Fujimoto, M., Brennand, K., Nakai, A., Mezger, V., Gage, F.H., Rakic, P., Hashimoto-Torii, K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. (2017) Nature Communications. 8:15157. DOI: 10.1038/ncomms15157

McConnell, M.J., Moran, J.V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J.A., Fasching, L., Flasch, D.A., Freed, D., Ganz, J., Jaffe, A.E., Kwan, K.Y., Kwon, M., Lodato, M.A., Mills, R.E., Paquola, A.C.M., Rodin, R.E., Rosenbluh, C., Sestan, N., Sherman, M.A., Shin, J.H., Song, S., Straub, R.E., Thorpe, J., Weinberger, D.R., Urban, A.E., Zhou, B., Gage, F.H., Lehner, T., Senthil, G., Walsh, C.A., Chess, A., Courchesne, E., Gleeson, J.G., Kidd, J.M., Park, P.J., Pevsner, J., Vaccarino, F.M., . Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. (2017) Science. 356(6336). DOI: 10.1126/science.aal1641

Kim, Y., Santos, R., Gage, F.H., Marchetto, M.C. Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. (2017) Frontiers in Cellular Neuroscience. 11:30. DOI: 10.3389/fncel.2017.00030

Ramsay, L., Marchetto, M.C., Caron, M., Chen, S.H., Busche, S., Kwan, T., Pastinen, T., Gage, F.H., Bourque, G. Conserved expression of transposon-derived non-coding transcripts in primate stem cells. (2017) BMC Genomics. 18(1):214. DOI: 10.1186/s12864-017-3568-y

Stern, S., Santos, R., Marchetto, M.C., Mendes, A.P., Rouleau, G.A., Biesmans, S., Wang, Q.W., Yao, J., Charnay, P., Bang, A.G., Alda, M., Gage, F.H. Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. (2017) Molecular Psychiatry. DOI: 10.1038/mp.2016.260

Adamowicz, D.H., Roy, S., Salmon, D.P., Galasko, D.R., Hansen, L.A., Masliah, E., Gage, F.H. Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. (2017) Journal of Neuroscience. 37(7):1675-1684. DOI: 10.1523/JNEUROSCI.3047-16.2016

Sarkar, A., Marchetto, M.C., Gage, F.H. Synaptic activity: An emerging player in schizophrenia. (2017) Brain Research. 1656:68-75. DOI: 10.1016/j.brainres.2015.12.028

Paquola, A.C.M., Erwin, J.A., Gage, F.H. Insights into the role of somatic mosaicism in the brain. (2017) Current Opinion in Systems Biology. 1:90-94. DOI: 10.1016/j.coisb.2016.12.004

Han, J., Gage, F.H. A role for miR-19 in the migration of adult-born neurons and schizophrenia. (2016) Neurogenesis. 3(1):e1251873. DOI: 10.1080/23262133.2016.1251873

Erwin, J.A., Paquola, A.C., Singer, T., Gallina, I., Novotny, M., Quayle, C., Bedrosian, T.A., Alves, F.I., Butcher, C.R., Herdy, J.R., Sarkar, A., Lasken, R.S., Muotri, A.R., Gage, F.H. L1-associated genomic regions are deleted in somatic cells of the healthy human brain. (2016) Nature Neuroscience. 19(12):1583-1591. DOI: 10.1038/nn.4388

Gonçalves, J.T., Schafer, S.T., Gage, F.H. Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016) Cell. 167(4):897-914. DOI: 10.1016/j.cell.2016.10.021

Vadodaria, K.C., Marchetto, M.C., Mertens, J., Gage, F.H. Generating human serotonergic neurons in vitro: Methodological advances. (2016) Bioessays. 38(11):1123-1129. DOI: 10.1002/bies.201600127

Bardy, C., van den Hurk, M., Kakaradov, B., Erwin, J.A., Jaeger, B.N., Hernandez, R.V., Eames, T., Paucar, A.A., Gorris, M., Marchand, C., Jappelli, R., Barron, J., Bryant, A.K., Kellogg, M., Lasken, R.S., Rutten, B.P., Steinbusch, H.W., Yeo, G.W., Gage, F.H. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. (2016) Molecular Psychiatry. 21(11):1573-1588. DOI: 10.1038/mp.2016.158

Du, H., Deng, W., Aimone, J.B., Ge, M., Parylak, S., Walch, K., Zhang, W., Cook, J., Song, H., Wang, L., Gage, F.H., Mu, Y. Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(37):E5501-10. DOI: 10.1073/pnas.1606951113

van den Hurk, M., Kenis, G., Bardy, C., van den Hove, D.L., Gage, F.H., Steinbusch, H.W., Rutten, B.P. Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. (2016) Epigenomics. 8(8):1131-49. DOI: 10.2217/epi-2016-0032

Gage, F.H., Guarente, L.P., Wagers, A.J. Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. (2016) Trends in Molecular Medicine. 22(8):633-4. DOI: 10.1016/j.molmed.2016.06.011

Chailangkarn, T., Trujillo, C.A., Freitas, B.C., Hrvoj-Mihic, B., Herai, R.H., Yu, D.X., Brown, T.T., Marchetto, M.C., Bardy, C., McHenry, L., Stefanacci, L., Järvinen, A., Searcy, Y.M., DeWitt, M., Wong, W., Lai, P., Ard, M.C., Hanson, K.L., Romero, S., Jacobs, B., Dale, A.M., Dai, L., Korenberg, J.R., Gage, F.H., Bellugi, U., Halgren, E., Semendeferi, K., Muotri, A.R. A human neurodevelopmental model for Williams syndrome. (2016) Nature. 536(7616):338-43. DOI: 10.1038/nature19067

Nuttle, X., Giannuzzi, G., Duyzend, M.H., Schraiber, J.G., Narvaiza, I., Sudmant, P.H., Penn, O., Chiatante, G., Malig, M., Huddleston, J., Benner, C., Camponeschi, F., Ciofi-Baffoni, S., Stessman, H.A., Marchetto, M.C., Denman, L., Harshman, L., Baker, C., Raja, A., Penewit, K., Janke, N., Tang, W.J., Ventura, M., Banci, L., Antonacci, F., Akey, J.M., Amemiya, C.T., Gage, F.H., Reymond, A., Eichler, E.E. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. (2016) Nature. 536(7615):205-9. DOI: 10.1038/nature19075

Padmanabhan, K., Osakada, F., Tarabrina, A., Kizer, E., Callaway, E.M., Gage, F.H., Sejnowski, T.J. Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. (2016) Journal of Neuroscience. 36(28):7535-45. DOI: 10.1523/JNEUROSCI.3358-15.2016

Han, J., Kim, H.J., Schafer, S.T., Paquola, A., Clemenson, G.D., Toda, T., Oh, J., Pankonin, A.R., Lee, B.S., Johnston, S.T., Sarkar, A., Denli, A.M., Gage, F.H. Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. (2016) Neuron. 91(1):79-89. DOI: 10.1016/j.neuron.2016.05.034

Mertens, J., Marchetto, M.C., Bardy, C., Gage, F.H. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. (2016) Nature Reviews Neuroscience. 17(7):424-37. DOI: 10.1038/nrn.2016.46

Ettle, B., Kerman, B.E., Valera, E., Gillmann, C., Schlachetzki, J.C., Reiprich, S., Büttner, C., Ekici, A.B., Reis, A., Wegner, M., Bäuerle, T., Riemenschneider, M.J., Masliah, E., Gage, F.H., Winkler, J. α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. (2016) Acta Neuropathologica. 132(1):59-75. DOI: 10.1007/s00401-016-1572-y

Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F.H., Hunter, T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. (2016) Elife. 5. DOI: 10.7554/eLife.13374

Gonçalves, J.T., Bloyd, C.W., Shtrahman, M., Johnston, S.T., Schafer, S.T., Parylak, S.L., Tran, T., Chang, T., Gage, F.H. In vivo imaging of dendritic pruning in dentate granule cells. (2016) Nature Neuroscience. 19(6):788-91. DOI: 10.1038/nn.4301

Bedrosian, T.A., Linker, S., Gage, F.H. Environment-driven somatic mosaicism in brain disorders. (2016) Genome Medicine. 8(1):58. DOI: 10.1186/s13073-016-0317-9

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

Poo, M.M., Pignatelli, M., Ryan, T.J., Tonegawa, S., Bonhoeffer, T., Martin, K.C., Rudenko, A., Tsai, L.H., Tsien, R.W., Fishell, G., Mullins, C., Gonçalves, J.T., Shtrahman, M., Johnston, S.T., Gage, F.H., Dan, Y., Long, J., Buzsáki, G., Stevens, C. What is memory? The present state of the engram. (2016) BMC Biology. 14:40. DOI: 10.1186/s12915-016-0261-6

Oedegaard, K.J., Alda, M., Anand, A., Andreassen, O.A., Balaraman, Y., Berrettini, W.H., Bhattacharjee, A., Brennand, K.J., Burdick, K.E., Calabrese, J.R., Calkin, C.V., Claasen, A., Coryell, W.H., Craig, D., DeModena, A., Frye, M., Gage, F.H., Gao, K., Garnham, J., Gershon, E., Jakobsen, P., Leckband, S.G., McCarthy, M.J., McInnis, M.G., Maihofer, A.X., Mertens, J., Morken, G., Nievergelt, C.M., Nurnberger, J., Pham, S., Schoeyen, H., Shekhtman, T., Shilling, P.D., Szelinger, S., Tarwater, B., Yao, J., Zandi, P.P., Kelsoe, J.R. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. (2016) BMC Psychiatry. 16:129. DOI: 10.1186/s12888-016-0732-x

Topol, A., Zhu, S., Hartley, B.J., English, J., Hauberg, M.E., Tran, N., Rittenhouse, C.A., Simone, A., Ruderfer, D.M., Johnson, J., Readhead, B., Hadas, Y., Gochman, P.A., Wang, Y.C., Shah, H., Cagney, G., Rapoport, J., Gage, F.H., Dudley, J.T., Sklar, P., Mattheisen, M., Cotter, D., Fang, G., Brennand, K.J. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. (2016) Cell Reports. 15(5):1024-1036. DOI: 10.1016/j.celrep.2016.03.090

Lacar, B., Linker, S.B., Jaeger, B.N., Krishnaswami, S., Barron, J., Kelder, M., Parylak, S., Paquola, A., Venepally, P., Novotny, M., O’Connor, C., Fitzpatrick, C., Erwin, J., Hsu, J.Y., Husband, D., McConnell, M.J., Lasken, R., Gage, F.H. Nuclear RNA-seq of single neurons reveals molecular signatures of activation. (2016) Nature Communications. 7:11022. DOI: 10.1038/ncomms11022

Harrison, B.J., Venkat, G., Lamb, J.L., Hutson, T.H., Drury, C., Rau, K.K., Bunge, M.B., Mendell, L.M., Gage, F.H., Johnson, R.D., Hill, C.E., Rouchka, E.C., Moon, L.D., Petruska, J.C. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. (2016) Journal of Neuroscience. 36(15):4259-75. DOI: 10.1523/JNEUROSCI.2423-15.2016

Otani, T., Marchetto, M.C., Gage, F.H., Simons, B.D., Livesey, F.J. 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. (2016) Cell Stem Cell. 18(4):467-80. DOI: 10.1016/j.stem.2016.03.003

Zheng, X., Boyer, L., Jin, M., Kim, Y., Fan, W., Bardy, C., Berggren, T., Evans, R.M., Gage, F.H., Hunter, T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. (2016) Elife. 5. DOI: 10.7554/eLife.13378

Mishra, H.K., Prots, I., Havlicek, S., Kohl, Z., Perez-Branguli, F., Boerstler, T., Anneser, L., Minakaki, G., Wend, H., Hampl, M., Leone, M., Brückner, M., Klucken, J., Reis, A., Boyer, L., Schuierer, G., Behrens, J., Lampert, A., Engel, F.B., Gage, F.H., Winkler, J., Winner, B. GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. (2016) Ann. Neurol. DOI: 10.1002/ana.24633

Krishnaswami, S.R., Grindberg, R.V., Novotny, M., Venepally, P., Lacar, B., Bhutani, K., Linker, S.B., Pham, S., Erwin, J.A., Miller, J.A., Hodge, R., McCarthy, J.K., Kelder, M., McCorrison, J., Aevermann, B.D., Fuertes, F.D., Scheuermann, R.H., Lee, J., Lein, E.S., Schork, N., McConnell, M.J., Gage, F.H., Lasken, R.S. Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. (2016) Nature Protocols. 11(3):499-524. DOI: 10.1038/nprot.2016.015

Johnston, S.T., Shtrahman, M., Parylak, S., Gonçalves, J.T., Gage, F.H. Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. (2016) Neurobiology of Learning and Memory. 129:60-8. DOI: 10.1016/j.nlm.2015.10.013

Weissman, I.L., Gage, F.H. A Mechanism for Somatic Brain Mosaicism. (2016) Cell. 164(4):593-5. DOI: 10.1016/j.cell.2016.01.048

Agre, P., Bertozzi, C., Bissell, M., Campbell, K.P., Cummings, R.D., Desai, U.R., Estes, M., Flotte, T., Fogleman, G., Gage, F., Ginsburg, D., Gordon, J.I., Hart, G., Hascall, V., Kiessling, L., Kornfeld, S., Lowe, J., Magnani, J., Mahal, L.K., Medzhitov, R., Roberts, R.J., Sackstein, R., Sarkar, R., Schnaar, R., Schwartz, N., Varki, A., Walt, D., Weissman, I. Training the next generation of biomedical investigators in glycosciences. (2016) Journal of Clinical Investigation. 126(2):405-8. DOI: 10.1172/JCI85905

Tang, X., Kim, J., Zhou, L., Wengert, E., Zhang, L., Wu, Z., Carromeu, C., Muotri, A.R., Marchetto, M.C., Gage, F.H., Chen, G. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(3):751-6. DOI: 10.1073/pnas.1524013113

Vadodaria, K.C., Mertens, J., Paquola, A., Bardy, C., Li, X., Jappelli, R., Fung, L., Marchetto, M.C., Hamm, M., Gorris, M., Koch, P., Gage, F.H. The different moods of human serotonergic neurons. (2016) Molecular Psychiatry. 21(1):3. DOI: 10.1038/mp.2015.202

Duricki, D.A., Hutson, T.H., Kathe, C., Soleman, S., Gonzalez-Carter, D., Petruska, J.C., Shine, H.D., Chen, Q., Wood, T.C., Bernanos, M., Cash, D., Williams, S.C., Gage, F.H., Moon, L.D. Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. (2016) Brain. 139(Pt 1):259-75. DOI: 10.1093/brain/awv341

Vadodaria, K.C., Mertens, J., Paquola, A., Bardy, C., Li, X., Jappelli, R., Fung, L., Marchetto, M.C., Hamm, M., Gorris, M., Koch, P., Gage, F.H. Generation of functional human serotonergic neurons from fibroblasts. (2016) Molecular Psychiatry. 21(1):49-61. DOI: 10.1038/mp.2015.161

Harrison, B.J., Venkat, G., Hutson, T., Rau, K.K., Bunge, M.B., Mendell, L.M., Gage, F.H., Johnson, R.D., Hill, C., Rouchka, E.C., Moon, L., Petruska, J.C. Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. (2015) Genomics Data. 6:249-52. DOI: 10.1016/j.gdata.2015.10.005

Brennand, K.J., Marchetto, M.C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F.M., Wu, J., Vanderhaeghen, P., Gage, F.H., Jaenisch, R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (2015) Stem Cell Reports. 5(6):933-45. DOI: 10.1016/j.stemcr.2015.10.011

Mertens, J., Paquola, A.C., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Gonçalves, J.T., Toda, T., Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. (2015) Cell Stem Cell. 17(6):705-18. DOI: 10.1016/j.stem.2015.09.001

Kim, H.J., Denli, A.M., Wright, R., Baul, T.D., Clemenson, G.D., Morcos, A.S., Zhao, C., Schafer, S.T., Gage, F.H., Kagalwala, M.N. REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II. (2015) Journal of Neuroscience. 35(44):14872-84. DOI: 10.1523/JNEUROSCI.4286-14.2015

Mertens, J., Wang, Q.W., Kim, Y., Yu, D.X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K.E., Zhang, J., Soltani, S., Eames, T., Schafer, S.T., Boyer, L., Marchetto, M.C., Nurnberger, J.I., Calabrese, J.R., Ødegaard, K.J., McCarthy, M.J., Zandi, P.P., Alda, M., Alba, M., Nievergelt, C.M., ., Mi, S., Brennand, K.J., Kelsoe, J.R., Gage, F.H., Yao, J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. (2015) Nature. 527(7576):95-9. DOI: 10.1038/nature15526

Denli, A.M., Narvaiza, I., Kerman, B.E., Pena, M., Benner, C., Marchetto, M.C., Diedrich, J.K., Aslanian, A., Ma, J., Moresco, J.J., Moore, L., Hunter, T., Saghatelian, A., Gage, F.H. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. (2015) Cell. 163(3):583-93. DOI: 10.1016/j.cell.2015.09.025

Mu, Y., Zhao, C., Toni, N., Yao, J., Gage, F.H. Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. (2015) Elife. 4:e07871. DOI: 10.7554/eLife.07871

Tashiro, A., Zhao, C., Suh, H., Gage, F.H. Preparation and Use of Retroviral Vectors for Labeling, Imaging, and Genetically Manipulating Cells. (2015) Cold Spring Harbor Protocols. 2015(10):883-8. DOI: 10.1101/pdb.top086363

Tashiro, A., Zhao, C., Suh, H., Gage, F.H. Analysis of Spine Motility of Newborn Granule Cells in Acute Brain Slices. (2015) Cold Spring Harbor Protocols. 2015(10):934-6. DOI: 10.1101/pdb.prot086397

Tashiro, A., Zhao, C., Suh, H., Gage, F.H. Imaging Newborn Granule Cells in Fixed Sections. (2015) Cold Spring Harbor Protocols. 2015(10):932-3. DOI: 10.1101/pdb.prot086389

Tashiro, A., Zhao, C., Suh, H., Gage, F.H. Purification and Injection of Retroviral Vectors. (2015) Cold Spring Harbor Protocols. 2015(10):925-31. DOI: 10.1101/pdb.prot086371

Prescott, S.L., Srinivasan, R., Marchetto, M.C., Grishina, I., Narvaiza, I., Selleri, L., Gage, F.H., Swigut, T., Wysocka, J. Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. (2015) Cell. 163(1):68-83. DOI: 10.1016/j.cell.2015.08.036

Kempermann, G., Song, H., Gage, F.H. Neurogenesis in the Adult Hippocampus. (2015) Cold Spring Harbor Perspectives in Biology. 7(9):a018812. DOI: 10.1101/cshperspect.a018812

Jovičić, A., Mertens, J., Boeynaems, S., Bogaert, E., Chai, N., Yamada, S.B., Paul, J.W., Sun, S., Herdy, J.R., Bieri, G., Kramer, N.J., Gage, F.H., Van Den Bosch, L., Robberecht, W., Gitler, A.D. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. (2015) Nature Neuroscience. 18(9):1226-9. DOI: 10.1038/nn.4085

Firth, A.L., Menon, T., Parker, G.S., Qualls, S.J., Lewis, B.M., Ke, E., Dargitz, C.T., Wright, R., Khanna, A., Gage, F.H., Verma, I.M. Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. (2015) Cell Reports. 12(9):1385-90. DOI: 10.1016/j.celrep.2015.07.062

Deng, W., Gage, F.H. The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. (2015) Frontiers in Systems Neuroscience. 9:34. DOI: 10.3389/fnsys.2015.00034

Han, J., Sarkar, A., Gage, F.H. MIR137: big impacts from small changes. (2015) Nature Neuroscience. 18(7):931-3. DOI: 10.1038/nn.4045

Zhao, C., Jou, J., Wolff, L.J., Sun, H., Gage, F.H. Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. (2015) Journal of Comparative Neurology. 523(10):1588. DOI: 10.1002/cne.23800

Krzisch, M., Temprana, S.G., Mongiat, L.A., Armida, J., Schmutz, V., Virtanen, M.A., Kocher-Braissant, J., Kraftsik, R., Vutskits, L., Conzelmann, K.K., Bergami, M., Gage, F.H., Schinder, A.F., Toni, N. Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus. (2015) Brain Structure & Function. 220(4):2027-42. DOI: 10.1007/s00429-014-0768-y

Kerman, B.E., Kim, H.J., Padmanabhan, K., Mei, A., Georges, S., Joens, M.S., Fitzpatrick, J.A., Jappelli, R., Chandross, K.J., August, P., Gage, F.H. In vitro myelin formation using embryonic stem cells. (2015) Development. 142(12):2213-25. DOI: 10.1242/dev.116517

Bardy, C., van den Hurk, M., Eames, T., Marchand, C., Hernandez, R.V., Kellogg, M., Gorris, M., Galet, B., Palomares, V., Brown, J., Bang, A.G., Mertens, J., Böhnke, L., Boyer, L., Simon, S., Gage, F.H. Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(20):E2725-34. DOI: 10.1073/pnas.1504393112

Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G.D., Pankratz, M., Tseng, T.W., Kaufman, S., Liddle, C., Yu, R.T., Downes, M., Pfaff, S.L., Auwerx, J., Gage, F.H., Evans, R.M. Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. (2015) Cell Metabolism. 21(4):628-36. DOI: 10.1016/j.cmet.2015.03.004

Adamowicz, D.H., Mertens, J., Gage, F.H. Alzheimer’s disease: distinct stages in neurogenic decline? (2015) Biological Psychiatry. 77(8):680-2. DOI: 10.1016/j.biopsych.2015.02.021

Amador-Arjona, A., Cimadamore, F., Huang, C.T., Wright, R., Lewis, S., Gage, F.H., Terskikh, A.V. SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(15):E1936-45. DOI: 10.1073/pnas.1421480112

Schafer, S.T., Han, J., Pena, M., von Bohlen Und Halbach, O., Peters, J., Gage, F.H. The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. (2015) Journal of Neuroscience. 35(12):4983-98. DOI: 10.1523/JNEUROSCI.4130-14.2015

Clemenson, G.D., Lee, S.W., Deng, W., Barrera, V.R., Iwamoto, K.S., Fanselow, M.S., Gage, F.H. Enrichment rescues contextual discrimination deficit associated with immediate shock. (2015) Hippocampus. 25(3):385-92. DOI: 10.1002/hipo.22380

Brennand, K., Savas, J.N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K.G., Kim, H.J., Topol, A., Ladran, I., Abdelrahim, M., Matikainen-Ankney, B., Chao, S.H., Mrksich, M., Rakic, P., Fang, G., Zhang, B., Yates, J.R., Gage, F.H. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. (2015) Molecular Psychiatry. 20(3):361-8. DOI: 10.1038/mp.2014.22

Pankevich, D.E., Altevogt, B.M., Dunlop, J., Gage, F.H., Hyman, S.E. Improving and accelerating drug development for nervous system disorders. (2014) Neuron. 84(3):546-53. DOI: 10.1016/j.neuron.2014.10.007

Kim, S.H., Steele, J.W., Lee, S.W., Clemenson, G.D., Carter, T.A., Treuner, K., Gadient, R., Wedel, P., Glabe, C., Barlow, C., Ehrlich, M.E., Gage, F.H., Gandy, S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. (2014) Molecular Psychiatry. 19(11):1235-42. DOI: 10.1038/mp.2014.87

Hook, V., Brennand, K.J., Kim, Y., Toneff, T., Funkelstein, L., Lee, K.C., Ziegler, M., Gage, F.H. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. (2014) Stem Cell Reports. 3(4):531-8. DOI: 10.1016/j.stemcr.2014.08.001

Aimone, J.B., Li, Y., Lee, S.W., Clemenson, G.D., Deng, W., Gage, F.H. Regulation and function of adult neurogenesis: from genes to cognition. (2014) Physiological Reviews. 94(4):991-1026. DOI: 10.1152/physrev.00004.2014

Jessberger, S., Gage, F.H. Adult neurogenesis: bridging the gap between mice and humans. (2014) Trends in Cell Biology. 24(10):558-63. DOI: 10.1016/j.tcb.2014.07.003

Winner, B., Marchetto, M.C., Winkler, J., Gage, F.H. Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease. (2014) Human Molecular Genetics. 23(R1):R27-34. DOI: 10.1093/hmg/ddu205

Gage, F., Nair, P. QnAs with Fred Gage. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(36):12958-9. DOI: 10.1073/pnas.1412625111

Erwin, J.A., Marchetto, M.C., Gage, F.H. Mobile DNA elements in the generation of diversity and complexity in the brain. (2014) Nature Reviews Neuroscience. 15(8):497-506. DOI: 10.1038/nrn3730

Gage, F., Pariente, N. On jumping genes and other things: Interview with Fred Gage, Adler Professor at the Salk Institute. (2014) EMBO Reports. 15(8):822-6. DOI: 10.15252/embr.201439088

Zhao, C., Jou, J., Wolff, L.J., Sun, H., Gage, F.H. Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. (2014) Journal of Comparative Neurology. 522(12):2756-66. DOI: 10.1002/cne.23581

Bekinschtein, P., Kent, B.A., Oomen, C.A., Clemenson, G.D., Gage, F.H., Saksida, L.M., Bussey, T.J. Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. (2014) Hippocampus. 24(8):905-11. DOI: 10.1002/hipo.22304

Stein, J.L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N.N., Hernández, I.A., Marchetto, M.C., Baker, D.K., Lu, D., Hinman, C.R., Lowe, J.K., Wexler, E.M., Muotri, A.R., Gage, F.H., Kosik, K.S., Geschwind, D.H. A quantitative framework to evaluate modeling of cortical development by neural stem cells. (2014) Neuron. 83(1):69-86. DOI: 10.1016/j.neuron.2014.05.035

Yu, D.X., Marchetto, M.C., Gage, F.H. How to make a hippocampal dentate gyrus granule neuron. (2014) Development. 141(12):2366-75. DOI: 10.1242/dev.096776

Lacar, B., Parylak, S.L., Vadodaria, K.C., Sarkar, A., Gage, F.H. Increasing the resolution of the adult neurogenesis picture. (2014) F1000 Prime Reports. 6:8. DOI: 10.12703/P6-8

Hrvoj-Mihic, B., Marchetto, M.C., Gage, F.H., Semendeferi, K., Muotri, A.R. Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. (2014) Biological Psychiatry. 75(12):929-35. DOI: 10.1016/j.biopsych.2013.08.007

Hashimoto-Torii, K., Torii, M., Fujimoto, M., Nakai, A., El Fatimy, R., Mezger, V., Ju, M.J., Ishii, S., Chao, S.H., Brennand, K.J., Gage, F.H., Rakic, P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. (2014) Neuron. 82(3):560-72. DOI: 10.1016/j.neuron.2014.03.002

Rockenstein, E., Nuber, S., Overk, C.R., Ubhi, K., Mante, M., Patrick, C., Adame, A., Trejo-Morales, M., Gerez, J., Picotti, P., Jensen, P.H., Campioni, S., Riek, R., Winkler, J., Gage, F.H., Winner, B., Masliah, E. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. (2014) Brain. 137(Pt 5):1496-513. DOI: 10.1093/brain/awu057

Havlicek, S., Kohl, Z., Mishra, H.K., Prots, I., Eberhardt, E., Denguir, N., Wend, H., Plötz, S., Boyer, L., Marchetto, M.C., Aigner, S., Sticht, H., Groemer, T.W., Hehr, U., Lampert, A., Schlötzer-Schrehardt, U., Winkler, J., Gage, F.H., Winner, B. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients’ neurons. (2014) Human Molecular Genetics. 23(10):2527-41. DOI: 10.1093/hmg/ddt644

Firth, A.L., Dargitz, C.T., Qualls, S.J., Menon, T., Wright, R., Singer, O., Gage, F.H., Khanna, A., Verma, I.M. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(17):E1723-30. DOI: 10.1073/pnas.1403470111

Pao, G.M., Zhu, Q., Perez-Garcia, C.G., Chou, S.J., Suh, H., Gage, F.H., O’Leary, D.D., Verma, I.M. Role of BRCA1 in brain development. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(13):E1240-8. DOI: 10.1073/pnas.1400783111

Crotti, A., Benner, C., Kerman, B.E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F.H., Cleveland, D.W., Glass, C.K. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. (2014) Nature Neuroscience. 17(4):513-21. DOI: 10.1038/nn.3668

Yu, D.X., Di Giorgio, F.P., Yao, J., Marchetto, M.C., Brennand, K., Wright, R., Mei, A., McHenry, L., Lisuk, D., Grasmick, J.M., Silberman, P., Silberman, G., Jappelli, R., Gage, F.H. Modeling hippocampal neurogenesis using human pluripotent stem cells. (2014) Stem Cell Reports. 2(3):295-310. DOI: 10.1016/j.stemcr.2014.01.009

Wright, R., Réthelyi, J.M., Gage, F.H. Enhancing induced pluripotent stem cell models of schizophrenia. (2014) JAMA Psychiatry. 71(3):334-5. DOI: 10.1001/jamapsychiatry.2013.4239

Vadodaria, K.C., Gage, F.H. SnapShot: adult hippocampal neurogenesis. (2014) Cell. 156(5):1114-1114.e1. DOI: 10.1016/j.cell.2014.02.029

Rangel, L.M., Alexander, A.S., Aimone, J.B., Wiles, J., Gage, F.H., Chiba, A.A., Quinn, L.K. Temporally selective contextual encoding in the dentate gyrus of the hippocampus. (2014) Nature Communications. 5:3181. DOI: 10.1038/ncomms4181

Parylak, S.L., Deng, W., Gage, F.H. Mother’s milk programs offspring’s cognition. (2014) Nature Neuroscience. 17(1):8-9. DOI: 10.1038/nn.3611

Marchetto, M.C., Gage, F.H. Your brain under the microscope: the promise of stem cells. (2014) Cerebrum. 2014:1.

Grindberg, R.V., Yee-Greenbaum, J.L., McConnell, M.J., Novotny, M., O’Shaughnessy, A.L., Lambert, G.M., Araúzo-Bravo, M.J., Lee, J., Fishman, M., Robbins, G.E., Lin, X., Venepally, P., Badger, J.H., Galbraith, D.W., Gage, F.H., Lasken, R.S. RNA-sequencing from single nuclei. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(49):19802-7. DOI: 10.1073/pnas.1319700110

Reilly, M.T., Faulkner, G.J., Dubnau, J., Ponomarev, I., Gage, F.H. The role of transposable elements in health and diseases of the central nervous system. (2013) Journal of Neuroscience. 33(45):17577-86. DOI: 10.1523/JNEUROSCI.3369-13.2013

McConnell, M.J., Lindberg, M.R., Brennand, K.J., Piper, J.C., Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R.S., Vermeesch, J.R., Hall, I.M., Gage, F.H. Mosaic copy number variation in human neurons. (2013) Science. 342(6158):632-7. DOI: 10.1126/science.1243472

Marchetto, M.C.N., Narvaiza, I., Denli, A.M., Benner, C., Lazzarini, T.A., Nathanson, J.L., Paquola, A.C.M., Desai, K.N., Herai, R.H., Weitzman, M.D., Yeo, G.W., Muotri, A.R., Gage, F.H. Differential L1 regulation in pluripotent stem cells of humans and apes. (2013) Nature. 503(7477):525-529. DOI: 10.1038/nature12686

Bekinschtein, P., Kent, B.A., Oomen, C.A., Clemenson, G.D., Gage, F.H., Saksida, L.M., Bussey, T.J. BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories. (2013) Cell Reports. 5(3):759-68. DOI: 10.1016/j.celrep.2013.09.027

Miller, J.A., Nathanson, J., Franjic, D., Shim, S., Dalley, R.A., Shapouri, S., Smith, K.A., Sunkin, S.M., Bernard, A., Bennett, J.L., Lee, C.K., Hawrylycz, M.J., Jones, A.R., Amaral, D.G., Šestan, N., Gage, F.H., Lein, E.S. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. (2013) Development. 140(22):4633-44. DOI: 10.1242/dev.097212

Gage, F.H., Temple, S. Neural stem cells: generating and regenerating the brain. (2013) Neuron. 80(3):588-601. DOI: 10.1016/j.neuron.2013.10.037

Deshmukh, V.A., Tardif, V., Lyssiotis, C.A., Green, C.C., Kerman, B., Kim, H.J., Padmanabhan, K., Swoboda, J.G., Ahmad, I., Kondo, T., Gage, F.H., Theofilopoulos, A.N., Lawson, B.R., Schultz, P.G., Lairson, L.L. A regenerative approach to the treatment of multiple sclerosis. (2013) Nature. 502(7471):327-332. DOI: 10.1038/nature12647

Herzog, C.D., Brown, L., Kruegel, B.R., Wilson, A., Tansey, M.G., Gage, F.H., Johnson, E.M., Bartus, R.T. Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). (2013) Neurobiol. Dis. 58:38-48. DOI: 10.1016/j.nbd.2013.04.011

Tang, X., Zhou, L., Wagner, A.M., Marchetto, M.C., Muotri, A.R., Gage, F.H., Chen, G. Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. (2013) Stem Cell Research. 11(2):743-57. DOI: 10.1016/j.scr.2013.05.002

Sung, T.C., Chen, Z., Thuret, S., Vilar, M., Gage, F.H., Riek, R., Lee, K.F. P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. (2013) PLOS One. 8(7):e69286. DOI: 10.1371/journal.pone.0069286

Yu, D.X., Marchetto, M.C., Gage, F.H. Therapeutic translation of iPSCs for treating neurological disease. (2013) Cell Stem Cell. 12(6):678-88. DOI: 10.1016/j.stem.2013.05.018

Vilchez, D., Boyer, L., Lutz, M., Merkwirth, C., Morantte, I., Tse, C., Spencer, B., Page, L., Masliah, E., Berggren, W.T., Gage, F.H., Dillin, A. FOXO4 is necessary for neural differentiation of human embryonic stem cells. (2013) Aging Cell. 12(3):518-22. DOI: 10.1111/acel.12067

Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M.C., Gage, F.H., Yamanaka, S., Inoue, H. Response to comment on “Drug screening for ALS using patient-specific induced pluripotent stem cells”. (2013) Science Translational Medicine. 5(188):188lr2. DOI: 10.1126/scitranslmed.3005697

Li, Y., Stam, F.J., Aimone, J.B., Goulding, M., Callaway, E.M., Gage, F.H. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(22):9106-11. DOI: 10.1073/pnas.1306912110

Rangel, L.M., Quinn, L.K., Chiba, A.A., Gage, F.H., Aimone, J.B. A hypothesis for temporal coding of young and mature granule cells. (2013) Frontiers in Neuroscience. 7:75. DOI: 10.3389/fnins.2013.00075

Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L.S., Cai, L., Thompson, R.C., Yang, B., Chen, Y., Johnson, P.F., Wu, C., Bu, G., Mobley, W.C., Zhang, D., Gage, F.H., Ranscht, B., Zhang, Y.W., Lipton, S.A., Hong, W., Xu, H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down’s syndrome. (2013) Nature Medicine. 19(4):473-80. DOI: 10.1038/nm.3117

Deng, W., Mayford, M., Gage, F.H. Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. (2013) Elife. 2:e00312. DOI: 10.7554/eLife.00312

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H., Hetzer, M.W. Dynamic association of NUP98 with the human genome. (2013) PLOS Genetics. 9(2):e1003308. DOI: 10.1371/journal.pgen.1003308

Shimozaki, K., Clemenson, G.D., Gage, F.H. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. (2013) Journal of Neuroscience. 33(9):4066-75. DOI: 10.1523/JNEUROSCI.4586-12.2013

Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J.M., Pulecio, J., Xia, Y., Li, M., Montserrat, N., Ruiz, S., Dubova, I., Rodriguez, C., Denli, A.M., Boscolo, F.S., Thiagarajan, R.D., Gage, F.H., Loring, J.F., Laurent, L.C., Izpisua Belmonte, J.C. Conversion of human fibroblasts to angioblast-like progenitor cells. (2013) Nature Methods. 10(1):77-83. DOI: 10.1038/nmeth.2255

Brennand, K.J., Simone, A., Tran, N., Gage, F.H. Modeling psychiatric disorders at the cellular and network levels. (2012) Molecular Psychiatry. 17(12):1239-53. DOI: 10.1038/mp.2012.20

Fava, M., Targum, S.D., Nierenberg, A.A., Bleicher, L.S., Carter, T.A., Wedel, P.C., Hen, R., Gage, F.H., Barlow, C. An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery. (2012) J Psychiatr Res. 46(12):1553-63. DOI: 10.1016/j.jpsychires.2012.08.013

Winner, B., Regensburger, M., Schreglmann, S., Boyer, L., Prots, I., Rockenstein, E., Mante, M., Zhao, C., Winkler, J., Masliah, E., Gage, F.H. Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. (2012) Journal of Neuroscience. 32(47):16906-16. DOI: 10.1523/JNEUROSCI.2723-12.2012

Bellin, M., Marchetto, M.C., Gage, F.H., Mummery, C.L. Induced pluripotent stem cells: the new patient? (2012) Nature Reviews Molecular Cell Biology. 13(11):713-26. DOI: 10.1038/nrm3448

Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W.T., Gage, F.H., Dillin, A. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. (2012) Nature. 489(7415):304-8. DOI: 10.1038/nature11468

Boyer, L.F., Campbell, B., Larkin, S., Mu, Y., Gage, F.H. Dopaminergic differentiation of human pluripotent cells. (2012) Curr Protoc Stem Cell Biol. Chapter 1:Unit1H.6. DOI: 10.1002/9780470151808.sc01h06s22

Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M.C., Gage, F.H., Yamanaka, S., Inoue, H. Drug screening for ALS using patient-specific induced pluripotent stem cells. (2012) Science Translational Medicine. 4(145):145ra104. DOI: 10.1126/scitranslmed.3004052

Giorgetti, A., Marchetto, M.C., Li, M., Yu, D., Fazzina, R., Mu, Y., Adamo, A., Paramonov, I., Cardoso, J.C., Monasterio, M.B., Bardy, C., Cassiani-Ingoni, R., Liu, G.H., Gage, F.H., Izpisua Belmonte, J.C. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(31):12556-61. DOI: 10.1073/pnas.1209523109

Marchetto, M.C., Gage, F.H. Modeling brain disease in a dish: really? (2012) Cell Stem Cell. 10(6):642-5. DOI: 10.1016/j.stem.2012.05.008

Zhao, C., Warner-Schmidt, J., Duman, R.S., Gage, F.H. Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat. (2012) Developmental Neurobiology. 72(6):937-42. DOI: 10.1002/dneu.20986

Yao, J., Mu, Y., Gage, F.H. Neural stem cells: mechanisms and modeling. (2012) Protein & Cell. 3(4):251-61. DOI: 10.1007/s13238-012-2033-6

Gage, F.H. Transplantation in the future. (2012) Progress in Brain Research. 200:7-13. DOI: 10.1016/B978-0-444-59575-1.00001-6

Gage, F.H., Muotri, A.R. What makes each brain unique. (2012) Sci. Am. 306(3):26-31.

Li, Y., Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(11):4290-5. DOI: 10.1073/pnas.1120754109

Ge, W.P., Miyawaki, A., Gage, F.H., Jan, Y.N., Jan, L.Y. Local generation of glia is a major astrocyte source in postnatal cortex. (2012) Nature. 484(7394):376-80. DOI: 10.1038/nature10959

Bracko, O., Singer, T., Aigner, S., Knobloch, M., Winner, B., Ray, J., Clemenson, G.D., Suh, H., Couillard-Despres, S., Aigner, L., Gage, F.H., Jessberger, S. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. (2012) Journal of Neuroscience. 32(10):3376-87. DOI: 10.1523/JNEUROSCI.4248-11.2012

Thuret, S., Thallmair, M., Horky, L.L., Gage, F.H. Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. (2012) PLOS One. 7(2):e30904. DOI: 10.1371/journal.pone.0030904

Shimozaki, K., Zhang, C.L., Suh, H., Denli, A.M., Evans, R.M., Gage, F.H. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. (2012) Journal of Biological Chemistry. 287(8):5969-78. DOI: 10.1074/jbc.M111.290403

Lee, S.W., Clemenson, G.D., Gage, F.H. New neurons in an aged brain. (2012) Behavioural Brain Research. 227(2):497-507. DOI: 10.1016/j.bbr.2011.10.009

Vivar, C., Potter, M.C., Choi, J., Lee, J.Y., Stringer, T.P., Callaway, E.M., Gage, F.H., Suh, H., van Praag, H. Monosynaptic inputs to new neurons in the dentate gyrus. (2012) Nature Communications. 3:1107. DOI: 10.1038/ncomms2101

Gage, F.H. ISSCR: beginning the next chapter. (2012) Cell Stem Cell. 10(1):29-31. DOI: 10.1016/j.stem.2011.12.009

Han, J., Denli, A.M., Gage, F.H. The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. (2012) Genes & Development. 26(1):6-10. DOI: 10.1101/gad.184416.111

Brennand, K.J., Gage, F.H. Modeling psychiatric disorders through reprogramming. (2012) Dis Model Mech. 5(1):26-32. DOI: 10.1242/dmm.008268

Israel, M.A., Yuan, S.H., Bardy, C., Reyna, S.M., Mu, Y., Herrera, C., Hefferan, M.P., Van Gorp, S., Nazor, K.L., Boscolo, F.S., Carson, C.T., Laurent, L.C., Marsala, M., Gage, F.H., Remes, A.M., Koo, E.H., Goldstein, L.S. Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells. (2012) Nature. 482(7384):216-20. DOI: 10.1038/nature10821

Boyce, V.S., Park, J., Gage, F.H., Mendell, L.M. Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats. (2012) Eur. J. Neurosci. 35(2):221-32. DOI: 10.1111/j.1460-9568.2011.07950.x

Mu, Y., Gage, F.H. Adult hippocampal neurogenesis and its role in Alzheimer’s disease. (2011) Mol Neurodegener. 6:85. DOI: 10.1186/1750-1326-6-85

Coufal, N.G., Garcia-Perez, J.L., Peng, G.E., Marchetto, M.C., Muotri, A.R., Mu, Y., Carson, C.T., Macia, A., Moran, J.V., Gage, F.H. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(51):20382-7. DOI: 10.1073/pnas.1100273108

Brennand, K.J., Gage, F.H. Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. (2011) Stem Cells. 29(12):1915-22. DOI: 10.1002/stem.762

Kuwabara, T., Kagalwala, M.N., Onuma, Y., Ito, Y., Warashina, M., Terashima, K., Sanosaka, T., Nakashima, K., Gage, F.H., Asashima, M. Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. (2011) EMBO Molecular Medicine. 3(12):742-54. DOI: 10.1002/emmm.201100177

Marchetto, M.C., Brennand, K.J., Boyer, L.F., Gage, F.H. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. (2011) Human Molecular Genetics. 20(R2):R109-15. DOI: 10.1093/hmg/ddr336

Hester, M.E., Murtha, M.J., Song, S., Rao, M., Miranda, C.J., Meyer, K., Tian, J., Boulting, G., Schaffer, D.V., Zhu, M.X., Pfaff, S.L., Gage, F.H., Kaspar, B.K. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. (2011) Mol. Ther. 19(10):1905-12. DOI: 10.1038/mt.2011.135

Zhu, Q., Pao, G.M., Huynh, A.M., Suh, H., Tonnu, N., Nederlof, P.M., Gage, F.H., Verma, I.M. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. (2011) Nature. 477(7363):179-84. DOI: 10.1038/nature10371

Shen, B., Xiang, Z., Miller, B., Louie, G., Wang, W., Noel, J.P., Gage, F.H., Wang, L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. (2011) Stem Cells. 29(8):1231-40. DOI: 10.1002/stem.679

Woods, N.B., Parker, A.S., Moraghebi, R., Lutz, M.K., Firth, A.L., Brennand, K.J., Berggren, W.T., Raya, A., Izpisúa Belmonte, J.C., Gage, F.H., Verma, I.M. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. (2011) Stem Cells. 29(7):1158-64. DOI: 10.1002/stem.657

Aimone, J.B., Deng, W., Gage, F.H. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. (2011) Neuron. 70(4):589-96. DOI: 10.1016/j.neuron.2011.05.010

Brennand, K.J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., McCarthy, S., Sebat, J., Gage, F.H. Modelling schizophrenia using human induced pluripotent stem cells. (2011) Nature. 473(7346):221-5. DOI: 10.1038/nature09915

Mu, Y., Zhao, C., Gage, F.H. Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. (2011) Journal of Neuroscience. 31(11):4113-23. DOI: 10.1523/JNEUROSCI.4913-10.2011

Aimone, J.B., Gage, F.H. Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. (2011) European Journal of Neuroscience. 33(6):1160-9. DOI: 10.1111/j.1460-9568.2011.07615.x

Winner, B., Kohl, Z., Gage, F.H. Neurodegenerative disease and adult neurogenesis. (2011) Eur. J. Neurosci. 33(6):1139-51. DOI: 10.1111/j.1460-9568.2011.07613.x

Winner, B., Jappelli, R., Maji, S.K., Desplats, P.A., Boyer, L., Aigner, S., Hetzer, C., Loher, T., Vilar, M., Campioni, S., Tzitzilonis, C., Soragni, A., Jessberger, S., Mira, H., Consiglio, A., Pham, E., Masliah, E., Gage, F.H., Riek, R. In vivo demonstration that alpha-synuclein oligomers are toxic. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(10):4194-9. DOI: 10.1073/pnas.1100976108

Winner, B., Melrose, H.L., Zhao, C., Hinkle, K.M., Yue, M., Kent, C., Braithwaite, A.T., Ogholikhan, S., Aigner, R., Winkler, J., Farrer, M.J., Gage, F.H. Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. (2011) Neurobiol. Dis. 41(3):706-16. DOI: 10.1016/j.nbd.2010.12.008

Yuan, S.H., Martin, J., Elia, J., Flippin, J., Paramban, R.I., Hefferan, M.P., Vidal, J.G., Mu, Y., Killian, R.L., Israel, M.A., Emre, N., Marsala, S., Marsala, M., Gage, F.H., Goldstein, L.S., Carson, C.T. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. (2011) PLOS One. 6(3):e17540. DOI: 10.1371/journal.pone.0017540

Kim, J.E., O’Sullivan, M.L., Sanchez, C.A., Hwang, M., Israel, M.A., Brennand, K., Deerinck, T.J., Goldstein, L.S., Gage, F.H., Ellisman, M.H., Ghosh, A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(7):3005-10. DOI: 10.1073/pnas.1007753108

Meng, X., Arocena, M., Penninger, J., Gage, F.H., Zhao, M., Song, B. PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. (2011) Exp. Neurol. 227(1):210-7. DOI: 10.1016/j.expneurol.2010.11.002

Ruiz, S., Brennand, K., Panopoulos, A.D., Herrerías, A., Gage, F.H., Izpisua-Belmonte, J.C. High-efficient generation of induced pluripotent stem cells from human astrocytes. (2010) PLOS One. 5(12):e15526. DOI: 10.1371/journal.pone.0015526

Marchetto, M.C., Carromeu, C., Acab, A., Yu, D., Yeo, G.W., Mu, Y., Chen, G., Gage, F.H., Muotri, A.R. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. (2010) Cell. 143(4):527-39. DOI: 10.1016/j.cell.2010.10.016

Mathews, E.A., Morgenstern, N.A., Piatti, V.C., Zhao, C., Jessberger, S., Schinder, A.F., Gage, F.H. A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. (2010) Journal of Comparative Neurology. 518(22):4479-90. DOI: 10.1002/cne.22489

Muotri, A.R., Marchetto, M.C., Coufal, N.G., Oefner, R., Yeo, G., Nakashima, K., Gage, F.H. L1 retrotransposition in neurons is modulated by MeCP2. (2010) Nature. 468(7322):443-6. DOI: 10.1038/nature09544

Ma, D.K., Marchetto, M.C., Guo, J.U., Ming, G.L., Gage, F.H., Song, H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. (2010) Nature Neuroscience. 13(11):1338-44. DOI: 10.1038/nn.2672

Aimone, J.B., Deng, W., Gage, F.H. Put them out to pasture? What are old granule cells good for, anyway…? (2010) Hippocampus. 20(10):1124-5. DOI: 10.1002/hipo.20867

Liu, D., Ou, L., Clemenson, G.D., Chao, C., Lutske, M.E., Zambetti, G.P., Gage, F.H., Xu, Y. Puma is required for p53-induced depletion of adult stem cells. (2010) Nature Cell Biology. 12(10):993-8. DOI: 10.1038/ncb2100

Petruska, J.C., Kitay, B., Boyce, V.S., Kaspar, B.K., Pearse, D.D., Gage, F.H., Mendell, L.M. Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. (2010) Eur. J. Neurosci. 32(6):997-1005. DOI: 10.1111/j.1460-9568.2010.07392.x

Mu, Y., Lee, S.W., Gage, F.H. Signaling in adult neurogenesis. (2010) Current Opinion in Neurobiology. 20(4):416-23. DOI: 10.1016/j.conb.2010.04.010

Singer, T., McConnell, M.J., Marchetto, M.C., Coufal, N.G., Gage, F.H. LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? (2010) Trends in Neurosciences. 33(8):345-54. DOI: 10.1016/j.tins.2010.04.001

Valdez, G., Tapia, J.C., Kang, H., Clemenson, G.D., Gage, F.H., Lichtman, J.W., Sanes, J.R. Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(33):14863-8. DOI: 10.1073/pnas.1002220107

Mira, H., Andreu, Z., Suh, H., Lie, D.C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M.A., Nakashima, K., Colak, D., Götz, M., Fariñas, I., Gage, F.H. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010) Cell Stem Cell. 7(1):78-89. DOI: 10.1016/j.stem.2010.04.016

Aimone, J.B., Deng, W., Gage, F.H. Adult neurogenesis: integrating theories and separating functions. (2010) Trends in Cognitive Sciences. 14(7):325-37. DOI: 10.1016/j.tics.2010.04.003

Deng, W., Aimone, J.B., Gage, F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010) Nature Reviews Neuroscience. 11(5):339-50. DOI: 10.1038/nrn2822

Marchetto, M.C., Winner, B., Gage, F.H. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. (2010) Human Molecular Genetics. 19(R1):R71-6. DOI: 10.1093/hmg/ddq159

Tronel, S., Fabre, A., Charrier, V., Oliet, S.H., Gage, F.H., Abrous, D.N. Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(17):7963-8. DOI: 10.1073/pnas.0914613107

Gage, F.H. Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus. (2010) Keio J Med. 59(3):79-83.

Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., Gage, F.H. Mechanisms underlying inflammation in neurodegeneration. (2010) Cell. 140(6):918-34. DOI: 10.1016/j.cell.2010.02.016

Gage, F. The promise and the challenge of modelling human disease in a dish. (2010) EMBO Molecular Medicine. 2(3):77-8. DOI: 10.1002/emmm.201000060

Qu, Q., Sun, G., Li, W., Yang, S., Ye, P., Zhao, C., Yu, R.T., Gage, F.H., Evans, R.M., Shi, Y. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. (2010) Nature Cell Biology. 12(1):31-40; sup pp 1-9. DOI: 10.1038/ncb2001

Nakashima, K., Kohyama, J., Namihira, M., Gage, F.H., Okano, H., Sawamoto, K. [Epigenetic mechanisms regulating neural cell fate determination]. (2009) No To Hattatsu. 41(6):411-4.

Jessberger, S., Gage, F.H., Eisch, A.J., Lagace, D.C. Making a neuron: Cdk5 in embryonic and adult neurogenesis. (2009) Trends in Neurosciences. 32(11):575-82. DOI: 10.1016/j.tins.2009.07.002

Deng, W., Saxe, M.D., Gallina, I.S., Gage, F.H. Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. (2009) Journal of Neuroscience. 29(43):13532-42. DOI: 10.1523/JNEUROSCI.3362-09.2009

Muotri, A.R., Zhao, C., Marchetto, M.C., Gage, F.H. Environmental influence on L1 retrotransposons in the adult hippocampus. (2009) Hippocampus. 19(10):1002-7. DOI: 10.1002/hipo.20564

Marchetto, M.C., Yeo, G.W., Kainohana, O., Marsala, M., Gage, F.H., Muotri, A.R. Transcriptional signature and memory retention of human-induced pluripotent stem cells. (2009) PLOS One. 4(9):e7076. DOI: 10.1371/journal.pone.0007076

Tamaki, S.J., Jacobs, Y., Dohse, M., Capela, A., Cooper, J.D., Reitsma, M., He, D., Tushinski, R., Belichenko, P.V., Salehi, A., Mobley, W., Gage, F.H., Huhn, S., Tsukamoto, A.S., Weissman, I.L., Uchida, N. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. (2009) Cell Stem Cell. 5(3):310-9. DOI: 10.1016/j.stem.2009.05.022

Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D.C., Moore, L., Nakashima, K., Asashima, M., Gage, F.H. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. (2009) Nature Neuroscience. 12(9):1097-105. DOI: 10.1038/nn.2360

Coufal, N.G., Garcia-Perez, J.L., Peng, G.E., Yeo, G.W., Mu, Y., Lovci, M.T., Morell, M., O’Shea, K.S., Moran, J.V., Gage, F.H. L1 retrotransposition in human neural progenitor cells. (2009) Nature. 460(7259):1127-31. DOI: 10.1038/nature08248

Overall, R.W., Kempermann, G., Peirce, J., Lu, L., Goldowitz, D., Gage, F.H., Goodwin, S., Smit, A.B., Airey, D.C., Rosen, G.D., Schalkwyk, L.C., Sutter, T.R., Nowakowski, R.S., Whatley, S., Williams, R.W. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. (2009) Frontiers in Neuroscience. 3:55. DOI: 10.3389/neuro.15.003.2009

Clelland, C.D., Choi, M., Romberg, C., Clemenson, G.D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L.M., Barker, R.A., Gage, F.H., Bussey, T.J. A functional role for adult hippocampal neurogenesis in spatial pattern separation. (2009) Science. 325(5937):210-3. DOI: 10.1126/science.1173215

Thuret, S., Toni, N., Aigner, S., Yeo, G.W., Gage, F.H. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. (2009) Hippocampus. 19(7):658-69. DOI: 10.1002/hipo.20550

Fortun, J., Puzis, R., Pearse, D.D., Gage, F.H., Bunge, M.B. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. (2009) J. Neurotrauma. 26(7):941-53. DOI: 10.1089/neu.2008.0807

Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F.H., Song, H., Lie, D.C. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. (2009) Journal of Neuroscience. 29(25):7966-77. DOI: 10.1523/JNEUROSCI.1054-09.2009

Li, Y., Mu, Y., Gage, F.H. Development of neural circuits in the adult hippocampus. (2009) Current Topics in Developmental Biology. 87:149-74. DOI: 10.1016/S0070-2153(09)01205-8

Suh, H., Deng, W., Gage, F.H. Signaling in adult neurogenesis. (2009) Annual Review of Cell and Developmental Biology. 25:253-75. DOI: 10.1146/annurev.cellbio.042308.113256

Andrews, M.R., Czvitkovich, S., Dassie, E., Vogelaar, C.F., Faissner, A., Blits, B., Gage, F.H., ffrench-Constant, C., Fawcett, J.W. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. (2009) Journal of Neuroscience. 29(17):5546-57. DOI: 10.1523/JNEUROSCI.0759-09.2009

Saijo, K., Winner, B., Carson, C.T., Collier, J.G., Boyer, L., Rosenfeld, M.G., Gage, F.H., Glass, C.K. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. (2009) Cell. 137(1):47-59. DOI: 10.1016/j.cell.2009.01.038

Denli, A.M., Cao, X., Gage, F.H. miR-9 and TLX: chasing tails in neural stem cells. (2009) Nature Structural & Molecular Biology. 16(4):346-7. DOI: 10.1038/nsmb0409-346

Zhao, C., Suh, H., Gage, F.H. Notch keeps ependymal cells in line. (2009) Nature Neuroscience. 12(3):243-5. DOI: 10.1038/nn0309-243

Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson, G.D., Consiglio, A., Lie, D.C., Squire, L.R., Gage, F.H. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009) Learn. Mem. 16(2):147-54. DOI: 10.1101/lm.1172609

Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X.D., Gage, F.H. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. (2009) Nature Structural & Molecular Biology. 16(2):130-7. DOI: 10.1038/nsmb.1545

Jessberger, S., Gage, F.H. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. (2009) Trends in Pharmacological Sciences. 30(2):61-5. DOI: 10.1016/j.tips.2008.11.003

Aimone, J.B., Wiles, J., Gage, F.H. Computational influence of adult neurogenesis on memory encoding. (2009) Neuron. 61(2):187-202. DOI: 10.1016/j.neuron.2008.11.026

Marumoto, T., Tashiro, A., Friedmann-Morvinski, D., Scadeng, M., Soda, Y., Gage, F.H., Verma, I.M. Development of a novel mouse glioma model using lentiviral vectors. (2009) Nature Medicine. 15(1):110-6. DOI: 10.1038/nm.1863

Rose, J.B., Crews, L., Rockenstein, E., Adame, A., Mante, M., Hersh, L.B., Gage, F.H., Spencer, B., Potkar, R., Marr, R.A., Masliah, E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer’s disease. (2009) Journal of Neuroscience. 29(4):1115-25. DOI: 10.1523/JNEUROSCI.4220-08.2009

Marchetto, M.C., Muotri, A.R., Mu, Y., Smith, A.M., Cezar, G.G., Gage, F.H. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. (2008) Cell Stem Cell. 3(6):649-57. DOI: 10.1016/j.stem.2008.10.001

Cao, X., Pfaff, S.L., Gage, F.H. YAP regulates neural progenitor cell number via the TEA domain transcription factor. (2008) Genes & Development. 22(23):3320-34. DOI: 10.1101/gad.1726608

Jessberger, S., Gage, F.H. Stem-cell-associated structural and functional plasticity in the aging hippocampus. (2008) Psychol Aging. 23(4):684-91. DOI: 10.1037/a0014188

Thompson, C.L., Pathak, S.D., Jeromin, A., Ng, L.L., MacPherson, C.R., Mortrud, M.T., Cusick, A., Riley, Z.L., Sunkin, S.M., Bernard, A., Puchalski, R.B., Gage, F.H., Jones, A.R., Bajic, V.B., Hawrylycz, M.J., Lein, E.S. Genomic anatomy of the hippocampus. (2008) Neuron. 60(6):1010-21. DOI: 10.1016/j.neuron.2008.12.008

Jessberger, S., Aigner, S., Clemenson, G.D., Toni, N., Lie, D.C., Karalay, O., Overall, R., Kempermann, G., Gage, F.H. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. (2008) PLOS Biology. 6(11):e272. DOI: 10.1371/journal.pbio.0060272

Spencer, B., Marr, R.A., Rockenstein, E., Crews, L., Adame, A., Potkar, R., Patrick, C., Gage, F.H., Verma, I.M., Masliah, E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. (2008) BMC Neurosci. 9:109. DOI: 10.1186/1471-2202-9-109

Kohyama, J., Kojima, T., Takatsuka, E., Yamashita, T., Namiki, J., Hsieh, J., Gage, F.H., Namihira, M., Okano, H., Sawamoto, K., Nakashima, K. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(46):18012-7. DOI: 10.1073/pnas.0808417105

Li, X., Barkho, B.Z., Luo, Y., Smrt, R.D., Santistevan, N.J., Liu, C., Kuwabara, T., Gage, F.H., Zhao, X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. (2008) Journal of Biological Chemistry. 283(41):27644-52. DOI: 10.1074/jbc.M804899200

Gage, F.H., Selzer, M.E. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. (2008) JAMA. 300(9):1013-4. DOI: 10.1001/jama.300.9.1013

Toni, N., Laplagne, D.A., Zhao, C., Lombardi, G., Ribak, C.E., Gage, F.H., Schinder, A.F. Neurons born in the adult dentate gyrus form functional synapses with target cells. (2008) Nature Neuroscience. 11(8):901-7. DOI: 10.1038/nn.2156

Jessberger, S., Toni, N., Clemenson, G.D., Ray, J., Gage, F.H. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. (2008) Nature Neuroscience. 11(8):888-93. DOI: 10.1038/nn.2148

Yeo, G.W., Coufal, N., Aigner, S., Winner, B., Scolnick, J.A., Marchetto, M.C., Muotri, A.R., Carson, C., Gage, F.H. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. (2008) Human Molecular Genetics. 17(R1):R67-75. DOI: 10.1093/hmg/ddn065

Zhao, C., Deng, W., Gage, F.H. Mechanisms and functional implications of adult neurogenesis. (2008) Cell. 132(4):645-60. DOI: 10.1016/j.cell.2008.01.033

Zhang, C.L., Zou, Y., He, W., Gage, F.H., Evans, R.M. A role for adult TLX-positive neural stem cells in learning and behaviour. (2008) Nature. 451(7181):1004-7. DOI: 10.1038/nature06562

Cezar, G.G., Quam, J.A., Smith, A.M., Rosa, G.J., Piekarczyk, M.S., Brown, J.F., Gage, F.H., Muotri, A.R. Identification of small molecules from human embryonic stem cells using metabolomics. (2007) Stem Cells Dev. 16(6):869-82. DOI: 10.1089/scd.2007.0022

Yao, W., Nathanson, J., Lian, I., Gage, F.H., Sung, L.A. Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. (2007) Gene Expr. Patterns. 8(1):36-46. DOI: 10.1016/j.modgep.2007.08.002

Suh, H., Consiglio, A., Ray, J., Sawai, T., D’Amour, K.A., Gage, F.H. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007) Cell Stem Cell. 1(5):515-28. DOI: 10.1016/j.stem.2007.09.002

Yeo, G.W., Xu, X., Liang, T.Y., Muotri, A.R., Carson, C.T., Coufal, N.G., Gage, F.H. Alternative splicing events identified in human embryonic stem cells and neural progenitors. (2007) PLOS Computational Biology. 3(10):1951-67. DOI: 10.1371/journal.pcbi.0030196

Muotri, A.R., Marchetto, M.C., Coufal, N.G., Gage, F.H. The necessary junk: new functions for transposable elements. (2007) Human Molecular Genetics. 16 Spec No:R159-67. DOI: 10.1093/hmg/ddm196

Jessberger, S., Zhao, C., Toni, N., Clemenson, G.D., Li, Y., Gage, F.H. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. (2007) Journal of Neuroscience. 27(35):9400-7. DOI: 10.1523/JNEUROSCI.2002-07.2007

Lanctot, P.M., Gage, F.H., Varki, A.P. The glycans of stem cells. (2007) Current Opinion in Chemical Biology. 11(4):373-80. DOI: 10.1016/j.cbpa.2007.05.032

Aigner, S., Denli, A.M., Gage, F.H. A novel model for an older remodeler: the BAF swap in neurogenesis. (2007) Neuron. 55(2):171-3. DOI: 10.1016/j.neuron.2007.07.004

Smrt, R.D., Eaves-Egenes, J., Barkho, B.Z., Santistevan, N.J., Zhao, C., Aimone, J.B., Gage, F.H., Zhao, X. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. (2007) Neurobiol. Dis. 27(1):77-89. DOI: 10.1016/j.nbd.2007.04.005

Garcia-Perez, J.L., Marchetto, M.C., Muotri, A.R., Coufal, N.G., Gage, F.H., O’Shea, K.S., Moran, J.V. LINE-1 retrotransposition in human embryonic stem cells. (2007) Human Molecular Genetics. 16(13):1569-77. DOI: 10.1093/hmg/ddm105

Toni, N., Teng, E.M., Bushong, E.A., Aimone, J.B., Zhao, C., Consiglio, A., van Praag, H., Martone, M.E., Ellisman, M.H., Gage, F.H. Synapse formation on neurons born in the adult hippocampus. (2007) Nature Neuroscience. 10(6):727-34. DOI: 10.1038/nn1908

El-Amouri, S.S., Zhu, H., Yu, J., Gage, F.H., Verma, I.M., Kindy, M.S. Neprilysin protects neurons against Abeta peptide toxicity. (2007) Brain Research. 1152:191-200. DOI: 10.1016/j.brainres.2007.03.072

Parent, J.M., Jessberger, S., Gage, F.H., Gong, C. Is neurogenesis reparative after status epilepticus? (2007) Epilepsia. 48 Suppl 8:69-71.

Jessberger, S., Nakashima, K., Clemenson, G.D., Mejia, E., Mathews, E., Ure, K., Ogawa, S., Sinton, C.M., Gage, F.H., Hsieh, J. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. (2007) Journal of Neuroscience. 27(22):5967-75. DOI: 10.1523/JNEUROSCI.0110-07.2007

van Praag, H., Lucero, M.J., Yeo, G.W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., Gage, F.H. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. (2007) Journal of Neuroscience. 27(22):5869-78. DOI: 10.1523/JNEUROSCI.0914-07.2007

Laplagne, D.A., Kamienkowski, J.E., Espósito, M.S., Piatti, V.C., Zhao, C., Gage, F.H., Schinder, A.F. Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. (2007) European Journal of Neuroscience. 25(10):2973-81. DOI: 10.1111/j.1460-9568.2007.05549.x

Jessberger, S., Clemenson, G.D., Gage, F.H. Spontaneous fusion and nonclonal growth of adult neural stem cells. (2007) Stem Cells. 25(4):871-4. DOI: 10.1634/stemcells.2006-0620

Tashiro, A., Makino, H., Gage, F.H. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. (2007) Journal of Neuroscience. 27(12):3252-9. DOI: 10.1523/JNEUROSCI.4941-06.2007

Leingärtner, A., Thuret, S., Kroll, T.T., Chou, S.J., Leasure, J.L., Gage, F.H., O’Leary, D.D. Cortical area size dictates performance at modality-specific behaviors. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(10):4153-8. DOI: 10.1073/pnas.0611723104

Cao, X., Pfaff, S.L., Gage, F.H. A functional study of miR-124 in the developing neural tube. (2007) Genes & Development. 21(5):531-6. DOI: 10.1101/gad.1519207

Pereira, A.C., Huddleston, D.E., Brickman, A.M., Sosunov, A.A., Hen, R., McKhann, G.M., Sloan, R., Gage, F.H., Brown, T.R., Small, S.A. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(13):5638-43. DOI: 10.1073/pnas.0611721104

Suzuki, S., Gerhold, L.M., Böttner, M., Rau, S.W., Dela Cruz, C., Yang, E., Zhu, H., Yu, J., Cashion, A.B., Kindy, M.S., Merchenthaler, I., Gage, F.H., Wise, P.M. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. (2007) Journal of Comparative Neurology. 500(6):1064-75. DOI: 10.1002/cne.21240

Jessberger, S., Gage, F.H. ZOOMING IN: a new high-resolution gene expression atlas of the brain. (2007) Mol. Syst. Biol. 3:75. DOI: 10.1038/msb4100122

Miller, T.M., Kim, S.H., Yamanaka, K., Hester, M., Umapathi, P., Arnson, H., Rizo, L., Mendell, J.R., Gage, F.H., Cleveland, D.W., Kaspar, B.K. Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(51):19546-51. DOI: 10.1073/pnas.0609411103

Suhonen, J., Ray, J., Blömer, U., Gage, F.H., Kaspar, B. Ex vivo and in vivo gene delivery to the brain. (2006) Current Protocols in Human Genetics. Chapter 13:Unit 13.3. DOI: 10.1002/0471142905.hg1303s51

Thallmair, M., Ray, J., Stallcup, W.B., Gage, F.H. Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis. (2006) Exp. Neurol. 202(1):167-78. DOI: 10.1016/j.expneurol.2006.05.025

Borrell, V., Kaspar, B.K., Gage, F.H., Callaway, E.M. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. (2006) Cereb. Cortex. 16(11):1571-83. DOI: 10.1093/cercor/bhj094

Ramirez-Amaya, V., Marrone, D.F., Gage, F.H., Worley, P.F., Barnes, C.A. Integration of new neurons into functional neural networks. (2006) Journal of Neuroscience. 26(47):12237-41. DOI: 10.1523/JNEUROSCI.2195-06.2006

Laplagne, D.A., Espósito, M.S., Piatti, V.C., Morgenstern, N.A., Zhao, C., van Praag, H., Gage, F.H., Schinder, A.F. Functional convergence of neurons generated in the developing and adult hippocampus. (2006) PLOS Biology. 4(12):e409. DOI: 10.1371/journal.pbio.0040409

Carson, C.T., Aigner, S., Gage, F.H. Stem cells: the good, bad and barely in control. (2006) Nature Medicine. 12(11):1237-8. DOI: 10.1038/nm1106-1237

Horky, L.L., Galimi, F., Gage, F.H., Horner, P.J. Fate of endogenous stem/progenitor cells following spinal cord injury. (2006) Journal of Comparative Neurology. 498(4):525-38. DOI: 10.1002/cne.21065

Jagasia, R., Song, H., Gage, F.H., Lie, D.C. New regulators in adult neurogenesis and their potential role for repair. (2006) Trends in Molecular Medicine. 12(9):400-5. DOI: 10.1016/j.molmed.2006.07.006

Tashiro, A., Sandler, V.M., Toni, N., Zhao, C., Gage, F.H. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. (2006) Nature. 442(7105):929-33. DOI: 10.1038/nature05028

Bhardwaj, R.D., Curtis, M.A., Spalding, K.L., Buchholz, B.A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F.H., Druid, H., Eriksson, P.S., Frisén, J. Neocortical neurogenesis in humans is restricted to development. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(33):12564-8. DOI: 10.1073/pnas.0605177103

Thuret, S., Moon, L.D., Gage, F.H. Therapeutic interventions after spinal cord injury. (2006) Nature Reviews Neuroscience. 7(8):628-43. DOI: 10.1038/nrn1955

Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(27):10294-9. DOI: 10.1073/pnas.0506945103

Tashiro, A., Zhao, C., Gage, F.H. Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. (2006) Nature Protocols. 1(6):3049-55. DOI: 10.1038/nprot.2006.473

Muotri, A.R., Gage, F.H. Generation of neuronal variability and complexity. (2006) Nature. 441(7097):1087-93. DOI: 10.1038/nature04959

Cao, X., Yeo, G., Muotri, A.R., Kuwabara, T., Gage, F.H. Noncoding RNAs in the mammalian central nervous system. (2006) Annual Review of Neuroscience. 29:77-103. DOI: 10.1146/annurev.neuro.29.051605.112839

Aimone, J.B., Wiles, J., Gage, F.H. Potential role for adult neurogenesis in the encoding of time in new memories. (2006) Nature Neuroscience. 9(6):723-7. DOI: 10.1038/nn1707

Barkho, B.Z., Song, H., Aimone, J.B., Smrt, R.D., Kuwabara, T., Nakashima, K., Gage, F.H., Zhao, X. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. (2006) Stem Cells Dev. 15(3):407-21. DOI: 10.1089/scd.2006.15.407

Zhang, C.L., Zou, Y., Yu, R.T., Gage, F.H., Evans, R.M. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. (2006) Genes & Development. 20(10):1308-20. DOI: 10.1101/gad.1413606

Jacobs, S., Lie, D.C., DeCicco, K.L., Shi, Y., DeLuca, L.M., Gage, F.H., Evans, R.M. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(10):3902-7. DOI: 10.1073/pnas.0511294103

Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. (2006) Nature Clinical Practice. Cardiovascular Medicine. 3 Suppl 1:S114-22. DOI: 10.1038/ncpcardio0442

Ray, J., Gage, F.H. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. (2006) Molecular and Cellular Neurosciences. 31(3):560-73. DOI: 10.1016/j.mcn.2005.11.010

Yang, H., Lu, P., McKay, H.M., Bernot, T., Keirstead, H., Steward, O., Gage, F.H., Edgerton, V.R., Tuszynski, M.H. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. (2006) Journal of Neuroscience. 26(8):2157-66. DOI: 10.1523/JNEUROSCI.4070-05.2005

Zhao, C., Teng, E.M., Summers, R.G., Ming, G.L., Gage, F.H. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. (2006) Journal of Neuroscience. 26(1):3-11. DOI: 10.1523/JNEUROSCI.3648-05.2006

Battista, D., Ferrari, C.C., Gage, F.H., Pitossi, F.J. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. (2006) European Journal of Neuroscience. 23(1):83-93. DOI: 10.1111/j.1460-9568.2005.04539.x

Alisch, R.S., Garcia-Perez, J.L., Muotri, A.R., Gage, F.H., Moran, J.V. Unconventional translation of mammalian LINE-1 retrotransposons. (2006) Genes & Development. 20(2):210-24. DOI: 10.1101/gad.1380406

Kempermann, G., Chesler, E.J., Lu, L., Williams, R.W., Gage, F.H. Natural variation and genetic covariance in adult hippocampal neurogenesis. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(3):780-5. DOI: 10.1073/pnas.0510291103

Warashina, M., Min, K.H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G., Ding, S. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. (2006) Angew. Chem. Int. Ed. Engl. 45(4):591-3. DOI: 10.1002/anie.200503089

Pizzo, D.P., Coufal, N.G., Lortie, M.J., Gage, F.H., Thal, L.J. Regulatable acetylcholine-producing fibroblasts enhance cognitive performance. (2006) Mol. Ther. 13(1):175-82. DOI: 10.1016/j.ymthe.2005.08.001

Moon, L.D., Leasure, J.L., Gage, F.H., Bunge, M.B. Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. (2006) Restorative Neurology and Neuroscience. 24(3):147-61.

Muotri, A.R., Nakashima, K., Toni, N., Sandler, V.M., Gage, F.H. Development of functional human embryonic stem cell-derived neurons in mouse brain. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(51):18644-8. DOI: 10.1073/pnas.0509315102

Hsieh, J., Gage, F.H. Chromatin remodeling in neural development and plasticity. (2005) Current Opinion in Cell Biology. 17(6):664-71. DOI: 10.1016/j.ceb.2005.09.002

Genoud, S., Maricic, I., Kumar, V., Gage, F.H. Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. (2005) Journal of Neuroimmunology. 168(1-2):40-5. DOI: 10.1016/j.jneuroim.2005.06.033

Lie, D.C., Colamarino, S.A., Song, H.J., Désiré, L., Mira, H., Consiglio, A., Lein, E.S., Jessberger, S., Lansford, H., Dearie, A.R., Gage, F.H. Wnt signalling regulates adult hippocampal neurogenesis. (2005) Nature. 437(7063):1370-5. DOI: 10.1038/nature04108

Singer, O., Marr, R.A., Rockenstein, E., Crews, L., Coufal, N.G., Gage, F.H., Verma, I.M., Masliah, E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. (2005) Nature Neuroscience. 8(10):1343-9. DOI: 10.1038/nn1531

Gage, F.H., McAllister, A.K. Neuronal and glial cell biology. (2005) Current Opinion in Neurobiology. 15(5):497-9. DOI: 10.1016/j.conb.2005.08.010

van Praag, H., Shubert, T., Zhao, C., Gage, F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. (2005) Journal of Neuroscience. 25(38):8680-5. DOI: 10.1523/JNEUROSCI.1731-05.2005

Cummings, B.J., Uchida, N., Tamaki, S.J., Salazar, D.L., Hooshmand, M., Summers, R., Gage, F.H., Anderson, A.J. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(39):14069-74. DOI: 10.1073/pnas.0507063102

Aigner, S., Gage, F.H. A small gem with great powers: geminin keeps neural progenitors thriving. (2005) Developmental Cell. 9(2):171-2. DOI: 10.1016/j.devcel.2005.07.005

Zupanc, G.K., Hinsch, K., Gage, F.H. Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. (2005) Journal of Comparative Neurology. 488(3):290-319. DOI: 10.1002/cne.20571

Muotri, A.R., Chu, V.T., Marchetto, M.C., Deng, W., Moran, J.V., Gage, F.H. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. (2005) Nature. 435(7044):903-10. DOI: 10.1038/nature03663

Kuwabara, T., Hsieh, J., Nakashima, K., Warashina, M., Taira, K., Gage, F.H. The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. (2005) Nucleic Acids Symp Ser (Oxf).(49):87-8 DOI: 10.1093/nass/49.1.87

Lin, W., Dominguez, B., Yang, J., Aryal, P., Brandon, E.P., Gage, F.H., Lee, K.F. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. (2005) Neuron. 46(4):569-79. DOI: 10.1016/j.neuron.2005.04.002

Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P., Gage, F.H. Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. (2005) Ann. Neurol. 57(5):649-55. DOI: 10.1002/ana.20451

Scheel, J.R., Ray, J., Gage, F.H., Barlow, C. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. (2005) Nature Methods. 2(5):363-70. DOI: 10.1038/nmeth755

Miller, T.M., Kaspar, B.K., Kops, G.J., Yamanaka, K., Christian, L.J., Gage, F.H., Cleveland, D.W. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. (2005) Ann. Neurol. 57(5):773-6. DOI: 10.1002/ana.20453

Lilley, C.E., Carson, C.T., Muotri, A.R., Gage, F.H., Weitzman, M.D. DNA repair proteins affect the lifecycle of herpes simplex virus 1. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(16):5844-9. DOI: 10.1073/pnas.0501916102

Myers, C.P., Lewcock, J.W., Hanson, M.G., Gosgnach, S., Aimone, J.B., Gage, F.H., Lee, K.F., Landmesser, L.T., Pfaff, S.L. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. (2005) Neuron. 46(1):37-49. DOI: 10.1016/j.neuron.2005.02.022

Lein, E.S., Callaway, E.M., Albright, T.D., Gage, F.H. Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. (2005) Journal of Comparative Neurology. 485(1):1-10. DOI: 10.1002/cne.20426

Galimi, F., Summers, R.G., van Praag, H., Verma, I.M., Gage, F.H. A role for bone marrow-derived cells in the vasculature of noninjured CNS. (2005) Blood. 105(6):2400-2. DOI: 10.1182/blood-2004-02-0612

Martin, M.J., Muotri, A., Gage, F., Varki, A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. (2005) Nature Medicine. 11(2):228-32. DOI: 10.1038/nm1181

Hashimoto, M., Rockenstein, E., Mante, M., Crews, L., Bar-On, P., Gage, F.H., Marr, R., Masliah, E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. (2004) Gene Therapy. 11(23):1713-23. DOI: 10.1038/sj.gt.3302349

Hsieh, J., Nakashima, K., Kuwabara, T., Mejia, E., Gage, F.H. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(47):16659-64. DOI: 10.1073/pnas.0407643101

Chin, V.I., Taupin, P., Sanga, S., Scheel, J., Gage, F.H., Bhatia, S.N. Microfabricated platform for studying stem cell fates. (2004) Biotechnol. Bioeng. 88(3):399-415. DOI: 10.1002/bit.20254

Shihabuddin, L.S., Numan, S., Huff, M.R., Dodge, J.C., Clarke, J., Macauley, S.L., Yang, W., Taksir, T.V., Parsons, G., Passini, M.A., Gage, F.H., Stewart, G.R. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. (2004) Journal of Neuroscience. 24(47):10642-51. DOI: 10.1523/JNEUROSCI.3584-04.2004

Hsieh, J., Gage, F.H. Epigenetic control of neural stem cell fate. (2004) Current Opinion in Genetics & Development. 14(5):461-9. DOI: 10.1016/j.gde.2004.07.006

Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F.H., Vescovi, A.L., Naldini, L. Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(41):14835-40. DOI: 10.1073/pnas.0404180101

Schinder, A.F., Gage, F.H. A hypothesis about the role of adult neurogenesis in hippocampal function. (2004) Physiology (Bethesda). 19:253-61. DOI: 10.1152/physiol.00012.2004

Aimone, J.B., Leasure, J.L., Perreau, V.M., Thallmair, M., Gage. Spatial and temporal gene expression profiling of the contused rat spinal cord. (2004) Exp. Neurol. 189(2):204-21. DOI: 10.1016/j.expneurol.2004.05.042

Wurmser, A.E., Nakashima, K., Summers, R.G., Toni, N., D’Amour, K.A., Lie, D.C., Gage, F.H. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. (2004) Nature. 430(6997):350-6. DOI: 10.1038/nature02604

Pizzo, D.P., Paban, V., Coufal, N.G., Gage, F.H., Thal, L.J. Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector. (2004) Brain Research. Molecular Brain Research. 126(1):1-13. DOI: 10.1016/j.molbrainres.2004.03.006

Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F.H., Christie, B.R. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. (2004) Neuroscience. 124(1):71-9. DOI: 10.1016/j.neuroscience.2003.09.029

Brandon, E.P., Mellott, T., Pizzo, D.P., Coufal, N., D’Amour, K.A., Gobeske, K., Lortie, M., López-Coviella, I., Berse, B., Thal, L.J., Gage, F.H., Blusztajn, J.K. Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. (2004) Journal of Neuroscience. 24(24):5459-66. DOI: 10.1523/JNEUROSCI.1106-04.2004

Gage, F.H. Structural plasticity of the adult brain. (2004) Dialogues Clin Neurosci. 6(2):135-41.

Lie, D.C., Song, H., Colamarino, S.A., Ming, G.L., Gage, F.H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004) Annual Review of Pharmacology and Toxicology. 44:399-421. DOI: 10.1146/annurev.pharmtox.44.101802.121631

Marr, R.A., Guan, H., Rockenstein, E., Kindy, M., Gage, F.H., Verma, I., Masliah, E., Hersh, L.B. Neprilysin regulates amyloid Beta peptide levels. (2004) J. Mol. Neurosci. 22(1-2):5-11. DOI: 10.1385/JMN:22:1-2:5

Schaffer, D.V., Gage, F.H. Neurogenesis and neuroadaptation. (2004) Neuromolecular Med. 5(1):1-9. DOI: 10.1385/NMM:5:1:001

Wurmser, A.E., Palmer, T.D., Gage, F.H. Neuroscience. Cellular interactions in the stem cell niche. (2004) Science. 304(5675):1253-5. DOI: 10.1126/science.1099344

Aimone, J.B., Gage, F.H. Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics. (2004) Journal of Neuroscience Methods. 135(1-2):27-33. DOI: 10.1016/j.jneumeth.2003.11.016

Lein, E.S., Zhao, X., Gage, F.H. Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. (2004) Journal of Neuroscience. 24(15):3879-89. DOI: 10.1523/JNEUROSCI.4710-03.2004

Kempermann, G., Wiskott, L., Gage, F.H. Functional significance of adult neurogenesis. (2004) Current Opinion in Neurobiology. 14(2):186-91. DOI: 10.1016/j.conb.2004.03.001

Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K., Gage, F.H. A small modulatory dsRNA specifies the fate of adult neural stem cells. (2004) Cell. 116(6):779-93.

Markakis, E.A., Palmer, T.D., Randolph-Moore, L., Rakic, P., Gage, F.H. Novel neuronal phenotypes from neural progenitor cells. (2004) Journal of Neuroscience. 24(12):2886-97. DOI: 10.1523/JNEUROSCI.4161-03.2004

Hsieh, J., Aimone, J.B., Kaspar, B.K., Kuwabara, T., Nakashima, K., Gage, F.H. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. (2004) Journal of Cell Biology. 164(1):111-22. DOI: 10.1083/jcb.200308101

Shi, Y., Chichung Lie, D., Taupin, P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H., Evans, R.M. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. (2004) Nature. 427(6969):78-83. DOI: 10.1038/nature02211

Nakashima, K., Colamarino, S., Gage, F.H. Embryonic stem cells: staying plastic on plastic. (2004) Nature Medicine. 10(1):23-4. DOI: 10.1038/nm0104-23

Muotri, A.R., Gage, F.H. Vibrating in the background. (2003) Nature Genetics. 35(3):205-7. DOI: 10.1038/ng1103-205

Rhodes, J.S., van Praag, H., Jeffrey, S., Girard, I., Mitchell, G.S., Garland, T., Gage, F.H. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. (2003) Behavioral Neuroscience. 117(5):1006-16. DOI: 10.1037/0735-7044.117.5.1006

Dziewczapolski, G., Lie, D.C., Ray, J., Gage, F.H., Shults, C.W. Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats. (2003) Exp. Neurol. 183(2):653-64.

Gage, F.H. Brain, repair yourself. (2003) Sci. Am. 289(3):46-53.

D’Amour, K.A., Gage, F.H. Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100 Suppl :11866-72. DOI: 10.1073/pnas.1834200100

Gage, F.H., Verma, I.M. Stem cells at the dawn of the 21st century. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100 Suppl :11817-8. DOI: 10.1073/pnas.1834433100

Aberg, M.A., Aberg, N.D., Palmer, T.D., Alborn, A.M., Carlsson-Skwirut, C., Bang, P., Rosengren, L.E., Olsson, T., Gage, F.H., Eriksson, P.S. IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. (2003) Molecular and Cellular Neurosciences. 24(1):23-40.

Arvanian, V.L., Horner, P.J., Gage, F.H., Mendell, L.M. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. (2003) Journal of Neuroscience. 23(25):8706-12.

Kaspar, B.K., Lladó, J., Sherkat, N., Rothstein, J.D., Gage, F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. (2003) Science. 301(5634):839-42. DOI: 10.1126/science.1086137

Dickinson-Anson, H., Winkler, J., Fisher, L.J., Song, H.J., Poo, M.m., Gage, F.H. Acetylcholine-secreting cells improve age-induced memory deficits. (2003) Molecular Therapy. 8(1):51-61.

South, S.M., Kohno, T., Kaspar, B.K., Hegarty, D., Vissel, B., Drake, C.T., Ohata, M., Jenab, S., Sailer, A.W., Malkmus, S., Masuyama, T., Horner, P., Bogulavsky, J., Gage, F.H., Yaksh, T.L., Woolf, C.J., Heinemann, S.F., Inturrisi, C.E. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. (2003) Journal of Neuroscience. 23(12):5031-40.

Zhao, X., Ueba, T., Christie, B.R., Barkho, B., McConnell, M.J., Nakashima, K., Lein, E.S., Eadie, B.D., Willhoite, A.R., Muotri, A.R., Summers, R.G., Chun, J., Lee, K.F., Gage, F.H. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(11):6777-82. DOI: 10.1073/pnas.1131928100

Scheel, J.R., Garrett, L.J., Allen, D.M., Carter, T.A., Randolph-Moore, L., Gambello, M.J., Gage, F.H., Wynshaw-Boris, A., Barlow, C. An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues. (2003) Nucleic Acids Research. 31(10):e57.

Klassen, H.J., Imfeld, K.L., Kirov, I.I., Tai, L., Gage, F.H., Young, M.J., Berman, M.A. Expression of cytokines by multipotent neural progenitor cells. (2003) Cytokine. 22(3-4):101-6.

Brown, J., Cooper-Kuhn, C.M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F.H., Kuhn, H.G. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. (2003) European Journal of Neuroscience. 17(10):2042-6.

Brivanlou, A.H., Gage, F.H., Jaenisch, R., Jessell, T., Melton, D., Rossant, J. Stem cells. Setting standards for human embryonic stem cells. (2003) Science. 300(5621):913-6. DOI: 10.1126/science.1082940

Klassen, H., Imfeld, K.L., Ray, J., Young, M.J., Gage, F.H., Berman, M.A. The immunological properties of adult hippocampal progenitor cells. (2003) Vision Research. 43(8):947-56.

Marr, R.A., Rockenstein, E., Mukherjee, A., Kindy, M.S., Hersh, L.B., Gage, F.H., Verma, I.M., Masliah, E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. (2003) Journal of Neuroscience. 23(6):1992-6.

Brandon, E.P., Lin, W., D’Amour, K.A., Pizzo, D.P., Dominguez, B., Sugiura, Y., Thode, S., Ko, C.P., Thal, L.J., Gage, F.H., Lee, K.F. Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. (2003) Journal of Neuroscience. 23(2):539-49.

Lai, K., Kaspar, B.K., Gage, F.H., Schaffer, D.V. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. (2003) Nature Neuroscience. 6(1):21-7. DOI: 10.1038/nn983

Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., Gage, F.H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. (2003) Development. 130(2):391-9.

Horner, P.J., Gage, F.H. Regeneration in the adult and aging brain. (2002) Archives of Neurology. 59(11):1717-20.

Zhao, X., Gage, F.H. Expressing the central nervous system. (2002) Neurochem. Res. 27(10):953-4.

Taupin, P., Gage, F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. (2002) Journal of Neuroscience Research. 69(6):745-9. DOI: 10.1002/jnr.10378

Tamaki, S., Eckert, K., He, D., Sutton, R., Doshe, M., Jain, G., Tushinski, R., Reitsma, M., Harris, B., Tsukamoto, A., Gage, F., Weissman, I., Uchida, N. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. (2002) Journal of Neuroscience Research. 69(6):976-86. DOI: 10.1002/jnr.10412

Lie, D.C., Dziewczapolski, G., Willhoite, A.R., Kaspar, B.K., Shults, C.W., Gage, F.H. The adult substantia nigra contains progenitor cells with neurogenic potential. (2002) Journal of Neuroscience. 22(15):6639-49. DOI: 20026700

Kempermann, G., Gast, D., Gage, F.H. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. (2002) Ann. Neurol. 52(2):135-43. DOI: 10.1002/ana.10262

Kempermann, G., Gage, F.H. Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. (2002) European Journal of Neuroscience. 16(1):129-36.

Horner, P.J., Thallmair, M., Gage, F.H. Defining the NG2-expressing cell of the adult CNS. (2002) Journal of Neurocytology. 31(6-7):469-80.

Song, H., Stevens, C.F., Gage, F.H. Astroglia induce neurogenesis from adult neural stem cells. (2002) Nature. 417(6884):39-44. DOI: 10.1038/417039a

Song, H.J., Stevens, C.F., Gage, F.H. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. (2002) Nature Neuroscience. 5(5):438-45. DOI: 10.1038/nn844

Wurmser, A.E., Gage, F.H. Stem cells: cell fusion causes confusion. (2002) Nature. 416(6880):485-7. DOI: 10.1038/416485a

Kempermann, G., Gage, F.H. Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis. (2002) Brain Res. Dev. Brain Res. 134(1-2):1-12.

van Praag, H., Gage, F.H. Genetics of childhood disorders: XXXVI. Stem cell research, part 1: New neurons in the adult brain. (2002) J Am Acad Child Adolesc Psychiatry. 41(3):354-6.

D’Amour, K.A., Gage, F.H. Are somatic stem cells pluripotent or lineage-restricted? (2002) Nature Medicine. 8(3):213-4. DOI: 10.1038/nm0302-213

van Praag, H., Schinder, A.F., Christie, B.R., Toni, N., Palmer, T.D., Gage, F.H. Functional neurogenesis in the adult hippocampus. (2002) Nature. 415(6875):1030-4. DOI: 10.1038/4151030a

Kaspar, B.K., Vissel, B., Bengoechea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E.P., Schaffer, D., Verma, I.M., Lee, K.F., Heinemann, S.F., Gage, F.H. Adeno-associated virus effectively mediates conditional gene modification in the brain. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(4):2320-5. DOI: 10.1073/pnas.042678699

Gage, F.H. Neurogenesis in the adult brain. (2002) Journal of Neuroscience. 22(3):612-3.

Kaspar, B.K., Erickson, D., Schaffer, D., Hinh, L., Gage, F.H., Peterson, D.A. Targeted retrograde gene delivery for neuronal protection. (2002) Mol. Ther. 5(1):50-6. DOI: 10.1006/mthe.2001.0520

Vallières, L., Campbell, I.L., Gage, F.H., Sawchenko, P.E. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. (2002) Journal of Neuroscience. 22(2):486-92.

Zhao, X., Lein, E.S., He, A., Smith, S.C., Aston, C., Gage, F.H. Transcriptional profiling reveals strict boundaries between hippocampal subregions. (2001) Journal of Comparative Neurology. 441(3):187-96.

Pfeifer, A., Brandon, E.P., Kootstra, N., Gage, F.H., Verma, I.M. Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(20):11450-5. DOI: 10.1073/pnas.201415498

Chu, V.T., Gage, F.H. Chipping away at stem cells. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(14):7652-3. DOI: 10.1073/pnas.141244198

van Praag, H., Barlow, C., Gage, F.H. Are drug targets missed owing to lack of physical activity? – Reply. (2001) Drug Discov. Today. 6(12):615-617.

Ray, J., Gage, F.H. Construction of cells expressing neurotrophins. (2001) Methods in Molecular Biology. 169:115-33.

Matsuura, N., Lie, D.C., Hoshimaru, M., Asahi, M., Hojo, M., Ishizaki, R., Hashimoto, N., Noji, S., Ohuchi, H., Yoshioka, H., Gage, F.H. Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line. (2001) Journal of Neuroscience. 21(12):4326-35.

Palmer, T.D., Schwartz, P.H., Taupin, P., Kaspar, B., Stein, S.A., Gage, F.H. Cell culture. Progenitor cells from human brain after death. (2001) Nature. 411(6833):42-3. DOI: 10.1038/35075141

Suhr, S.T., Senut, M.C., Whitelegge, J.P., Faull, K.F., Cuizon, D.B., Gage, F.H. Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. (2001) Journal of Cell Biology. 153(2):283-94.

Anderson, D.J., Gage, F.H., Weissman, I.L. Can stem cells cross lineage boundaries? (2001) Nature Medicine. 7(4):393-5. DOI: 10.1038/86439

Allen, D.M., van Praag, H., Ray, J., Weaver, Z., Winrow, C.J., Carter, T.A., Braquet, R., Harrington, E., Ried, T., Brown, K.D., Gage, F.H., Barlow, C. Ataxia telangiectasia mutated is essential during adult neurogenesis. (2001) Genes & Development. 15(5):554-66. DOI: 10.1101/gad.869001

Weissman, I.L., Anderson, D.J., Gage, F.H. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. (2001) Annual Review of Cell and Developmental Biology. 17:387-403. DOI: 10.1146/annurev.cellbio.17.1.387

van Praag, H., Kempermann, G., Gage, F.H. Neural consequences of environmental enrichment. (2000) Nature Reviews Neuroscience. 1(3):191-8. DOI: 10.1038/35044558

Kempermann, G., van Praag, H., Gage, F.H. Activity-dependent regulation of neuronal plasticity and self repair. (2000) Progress in Brain Research. 127:35-48.

Uchida, N., Buck, D.W., He, D., Reitsma, M.J., Masek, M., Phan, T.V., Tsukamoto, A.S., Gage, F.H., Weissman, I.L. Direct isolation of human central nervous system stem cells. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(26):14720-5. DOI: 10.1073/pnas.97.26.14720

Shihabuddin, L.S., Horner, P.J., Ray, J., Gage, F.H. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. (2000) Journal of Neuroscience. 20(23):8727-35.

Taupin, P., Ray, J., Fischer, W.H., Suhr, S.T., Hakansson, K., Grubb, A., Gage, F.H. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. (2000) Neuron. 28(2):385-97.

Shults, C.W., Ray, J., Tsuboi, K., Gage, F.H. Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine. (2000) Brain Research. 883(2):192-204.

Horner, P.J., Gage, F.H. Regenerating the damaged central nervous system. (2000) Nature. 407(6807):963-70. DOI: 10.1038/35039559

Zoghbi, H.Y., Gage, F.H., Choi, D.W. Neurobiology of disease. (2000) Current Opinion in Neurobiology. 10(5):655-60.

Gage, F.H. Structural plasticity: cause, result, or correlate of depression. (2000) Biological Psychiatry. 48(8):713-4.

Palmer, T.D., Willhoite, A.R., Gage, F.H. Vascular niche for adult hippocampal neurogenesis. (2000) Journal of Comparative Neurology. 425(4):479-94.

Young, M.J., Ray, J., Whiteley, S.J., Klassen, H., Gage, F.H. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. (2000) Molecular and Cellular Neurosciences. 16(3):197-205. DOI: 10.1006/mcne.2000.0869

Verma, I.M., Gage, F.H. Genome and gene therapy. (2000) Molecular Therapy. 2(2):95. DOI: 10.1006/mthe.2000.0109

Kempermann, G., Gage, F.H. Neurogenesis in the adult hippocampus. (2000) Novartis Found. Symp. 231:220-35; discussion 235-41, 302.

Kafri, T., van Praag, H., Gage, F.H., Verma, I.M. Lentiviral vectors: regulated gene expression. (2000) Molecular Therapy. 1(6):516-21. DOI: 10.1006/mthe.2000.0083

Jacobs, B.L., van Praag, H., Gage, F.H. Adult brain neurogenesis and psychiatry: a novel theory of depression. (2000) Molecular Psychiatry. 5(3):262-9.

D’Amour, K., Gage, F.H. New tools for human developmental biology. (2000) Nature Biotechnology. 18(4):381-2. DOI: 10.1038/74429

Horner, P.J., Power, A.E., Kempermann, G., Kuhn, H.G., Palmer, T.D., Winkler, J., Thal, L.J., Gage, F.H. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. (2000) Journal of Neuroscience. 20(6):2218-28.

Gage, F.H. Mammalian neural stem cells. (2000) Science. 287(5457):1433-8.

Senut, M.C., Suhr, S.T., Kaspar, B., Gage, F.H. Intraneuronal aggregate formation and cell death after viral expression of expanded polyglutamine tracts in the adult rat brain. (2000) Journal of Neuroscience. 20(1):219-29.

Spain, B.H., Larson, C.J., Shihabuddin, L.S., Gage, F.H., Verma, I.M. Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(24):13920-5.

van Praag, H., Christie, B.R., Sejnowski, T.J., Gage, F.H. Running enhances neurogenesis, learning, and long-term potentiation in mice. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(23):13427-31.

Shihabuddin, L.S., Palmer, T.D., Gage, F.H. The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease. (1999) Mol Med Today. 5(11):474-80.

Sailer, A., Swanson, G.T., Pérez-Otaño, I., O’Leary, L., Malkmus, S.A., Dyck, R.H., Dickinson-Anson, H., Schiffer, H.H., Maron, C., Yaksh, T.L., Gage, F.H., O’Gorman, S., Heinemann, S.F. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice. (1999) Journal of Neuroscience. 19(20):8757-64.

Palmer, T.D., Markakis, E.A., Willhoite, A.R., Safar, F., Gage, F.H. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. (1999) Journal of Neuroscience. 19(19):8487-97.

Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D., Gage, F.H. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. (1999) Development. 126(18):4017-26.

Takahashi, M., Miyoshi, H., Verma, I.M., Gage, F.H. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. (1999) Journal of Virology. 73(9):7812-6.

Smith, D.E., Roberts, J., Gage, F.H., Tuszynski, M.H. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(19):10893-8.

Kempermann, G., Gage, F.H. Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. (1999) Hippocampus. 9(3):321-32. DOI: 10.1002/(SICI)1098-1063(1999)9:3<321::AID-HIPO11>3

Kempermann, G., Gage, F.H. New nerve cells for the adult brain. (1999) Sci. Am. 280(5):48-53.

Steward, O., Schauwecker, P.E., Guth, L., Zhang, Z., Fujiki, M., Inman, D., Wrathall, J., Kempermann, G., Gage, F.H., Saatman, K.E., Raghupathi, R., McIntosh, T. Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. (1999) Experimental Neurology. 157(1):19-42. DOI: 10.1006/exnr.1999.7040

Senut, M.C., Gage, F.H. Prenatal gene therapy: can the technical hurdles be overcome? (1999) Mol Med Today. 5(4):152-6.

Markakis, E.A., Gage, F.H. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. (1999) Journal of Comparative Neurology. 406(4):449-60.

Ueba, T., Kaspar, B., Zhao, X., Gage, F.H. Repression of human fibroblast growth factor 2 by a novel transcription factor. (1999) Journal of Biological Chemistry. 274(15):10382-7.

van Praag, H., Kempermann, G., Gage, F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. (1999) Nature Neuroscience. 2(3):266-70. DOI: 10.1038/6368

Suhr, S.T., Gage, F.H. Gene therapy in the central nervous system: the use of recombinant retroviruses. (1999) Archives of Neurology. 56(3):287-92.

Peterson, D.A., Dickinson-Anson, H.A., Leppert, J.T., Lee, K.F., Gage, F.H. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. (1999) Journal of Comparative Neurology. 404(1):1-20.

Takahashi, J., Palmer, T.D., Gage, F.H. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. (1999) Journal of Neurobiology. 38(1):65-81.

Shihabuddin, L.S., Ray, J., Gage, F.H. Stem cell technology for basic science and clinical applications. (1999) Archives of Neurology. 56(1):29-32.

Kafri, T., van Praag, H., Ouyang, L., Gage, F.H., Verma, I.M. A packaging cell line for lentivirus vectors. (1999) Journal of Virology. 73(1):576-84.

Mandel, R.J., Gage, F.H., Clevenger, D.G., Spratt, S.K., Snyder, R.O., Leff, S.E. Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced deg (1999) Experimental Neurology. 155(1):59-64. DOI: 10.1006/exnr.1998.6961

Chiang, M.Y., Misner, D., Kempermann, G., Schikorski, T., Giguère, V., Sucov, H.M., Gage, F.H., Stevens, C.F., Evans, R.M. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. (1998) Neuron. 21(6):1353-61.

Takahashi, M., Palmer, T.D., Takahashi, J., Gage, F.H. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. (1998) Molecular and Cellular Neurosciences. 12(6):340-8. DOI: 10.1006/mcne.1998.0721

Eriksson, P.S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.M., Nordborg, C., Peterson, D.A., Gage, F.H. Neurogenesis in the adult human hippocampus. (1998) Nature Medicine. 4(11):1313-7. DOI: 10.1038/3305

Kempermann, G., Kuhn, H.G., Winkler, J., Gage, F.H. [New nerve cells for the adult brain. Adult neurogenesis and stem cell concepts in neurologic research]. (1998) Nervenarzt. 69(10):851-7.

Gage, F.H. Stem cells of the central nervous system. (1998) Current Opinion in Neurobiology. 8(5):671-6.

Miyoshi, H., Blömer, U., Takahashi, M., Gage, F.H., Verma, I.M. Development of a self-inactivating lentivirus vector. (1998) Journal of Virology. 72(10):8150-7.

Varki, A., Wills, C., Perlmutter, D., Woodruff, D., Gage, F.H., Moore, J., Semendeferi, K., Bernirschke, K., Katzman, R., Doolittle, R., Bullock, T. Great Ape Phenome Project? (1998) Science. 282(5387):239-40.

Varki, A., Wills, C., Perlmutter, D., Woodruff, D., Gage, F.H., Moore, J., Semendeferi, K., Bernirschke, K., Katzman, R., Doolittle, R., Bullock, T. Great Ape Phenome Project? (1998) Science. 282(5387):239-40.

Aubert, I., Ridet, J.L., Schachner, M., Rougon, G., Gage, F.H. Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation. (1998) Journal of Comparative Neurology. 399(1):1-19.

Berger, F., Gage, F.H., Vijayaraghavan, S. Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. (1998) Journal of Neuroscience. 18(17):6871-81.

Gage, F.H., Kempermann, G., Palmer, T.D., Peterson, D.A., Ray, J. Multipotent progenitor cells in the adult dentate gyrus. (1998) Journal of Neurobiology. 36(2):249-66.

Suhr, S.T., Gil, E.B., Senut, M.C., Gage, F.H. High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(14):7999-8004.

Winkler, J., Thal, L.J., Gage, F.H., Fisher, L.J. Cholinergic strategies for Alzheimer’s disease. (1998) Journal of Molecular Medicine. 76(8):555-67.

McTigue, D.M., Horner, P.J., Stokes, B.T., Gage, F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. (1998) Journal of Neuroscience. 18(14):5354-65.

Kempermann, G., Brandon, E.P., Gage, F.H. Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. (1998) Current Biology. 8(16):939-42.

Dickinson-Anson, H., Aubert, I., Gage, F.H., Fisher, L.J. Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion. (1998) Neuroscience. 84(3):771-81.

Kempermann, G., Kuhn, H.G., Gage, F.H. Experience-induced neurogenesis in the senescent dentate gyrus. (1998) Journal of Neuroscience. 18(9):3206-12.

Kempermann, G., Gage, F.H. Closer to neurogenesis in adult humans. (1998) Nature Medicine. 4(5):555-7.

Senut, M.C., Suhr, S.T., Gage, F.H. Gene transfer to the rodent placenta in situ. A new strategy for delivering gene products to the fetus. (1998) Journal of Clinical Investigation. 101(8):1565-71. DOI: 10.1172/JCI1959

Mulle, C., Sailer, A., Pérez-Otaño, I., Dickinson-Anson, H., Castillo, P.E., Bureau, I., Maron, C., Gage, F.H., Mann, J.R., Bettler, B., Heinemann, S.F. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. (1998) Nature. 392(6676):601-5. DOI: 10.1038/33408

Gage, F.H. Cell therapy. (1998) Nature. 392(6679 Suppl):18-24.

Blömer, U., Kafri, T., Randolph-Moore, L., Verma, I.M., Gage, F.H. Bcl-xL protects adult septal cholinergic neurons from axotomized cell death. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(5):2603-8.

Shihabuddin, L.S., Ray, J., Gage, F.H. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. (1997) Exp. Neurol. 148(2):577-86. DOI: 10.1006/exnr.1997.6697

Ridet, J.L., Malhotra, S.K., Privat, A., Gage, F.H. Reactive astrocytes: cellular and molecular cues to biological function. (1997) Trends in Neurosciences. 20(12):570-7.

Kafri, T., Blömer, U., Peterson, D.A., Gage, F.H., Verma, I.M. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. (1997) Nature Genetics. 17(3):314-7. DOI: 10.1038/ng1197-314

Kempermann, G., Kuhn, H.G., Gage, F.H. Genetic influence on neurogenesis in the dentate gyrus of adult mice. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(19):10409-14.

Miyoshi, H., Takahashi, M., Gage, F.H., Verma, I.M. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(19):10319-23.

Blömer, U., Naldini, L., Kafri, T., Trono, D., Verma, I.M., Gage, F.H. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. (1997) Journal of Virology. 71(9):6641-9.

Kuhn, H.G., Winkler, J., Kempermann, G., Thal, L.J., Gage, F.H. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. (1997) Journal of Neuroscience. 17(15):5820-9.

Peterson, D.A., Leppert, J.T., Lee, K.F., Gage, F.H. Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75. (1997) Science. 277(5327):837-9.

Grill, R., Murai, K., Blesch, A., Gage, F.H., Tuszynski, M.H. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. (1997) Journal of Neuroscience. 17(14):5560-72.

Schinstine, M., Ray, J., Gage, F.H. Potential effect of cytokines on transgene expression in primary fibroblasts implanted into the rat brain. (1997) Brain Res. Mol. Brain Res. 47(1-2):195-201.

Ray, J., Baird, A., Gage, F.H. A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells. (1997) Proceedings of the National Academy of Sciences of the United